MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense

Carmen Aguilar; Miguel Mano; Ana Eulalio

doi:10.1016/j.tim.2018.10.011

MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense

Carmen Aguilar, Miguel Mano, Ana Eulalio^*

^*Corresponding author for this work

Cardiovascular Sciences

Research output: Contribution to journal › Review article › peer-review

76 Citations (Scopus)

Abstract

MicroRNAs are a class of small noncoding RNAs that act as major post-transcriptional regulators of gene expression. They are currently recognized for their important role in the intricate interaction between host and bacterial pathogens, either as part of the host immune response to neutralize infection, or as a molecular strategy employed by bacteria to hijack host pathways for their own benefit. Here, we summarize recent advances on the function of miRNAs during infection of mammalian hosts by bacterial pathogens, highlighting key cellular pathways. In addition, we discuss emerging themes in this field, including the participation of miRNAs in host–microbiota crosstalk and cell-to-cell communication.

Original language	English
Pages (from-to)	206-218
Number of pages	13
Journal	Trends in Microbiology
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.tim.2018.10.011
Publication status	Published - Mar 2019

Keywords

bacterial pathogen
cell-to-cell communication
host–pathogen interaction
microbiota
microRNA

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tim.2018.10.011

Cite this

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title = "MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense",

abstract = "MicroRNAs are a class of small noncoding RNAs that act as major post-transcriptional regulators of gene expression. They are currently recognized for their important role in the intricate interaction between host and bacterial pathogens, either as part of the host immune response to neutralize infection, or as a molecular strategy employed by bacteria to hijack host pathways for their own benefit. Here, we summarize recent advances on the function of miRNAs during infection of mammalian hosts by bacterial pathogens, highlighting key cellular pathways. In addition, we discuss emerging themes in this field, including the participation of miRNAs in host–microbiota crosstalk and cell-to-cell communication.",

keywords = "bacterial pathogen, cell-to-cell communication, host–pathogen interaction, microbiota, microRNA",

author = "Carmen Aguilar and Miguel Mano and Ana Eulalio",

note = "Funding Information: The work in AE and MM laboratories on microRNAs and infection was supported by the ERA-NET Infect-ERA CampyRNA and the FCT R&D grant (#POCI-01-0145-FEDER-029999 ). Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

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language = "English",

volume = "27",

pages = "206--218",

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TY - JOUR

T1 - MicroRNAs at the Host–Bacteria Interface

T2 - Host Defense or Bacterial Offense

AU - Aguilar, Carmen

AU - Mano, Miguel

AU - Eulalio, Ana

N1 - Funding Information: The work in AE and MM laboratories on microRNAs and infection was supported by the ERA-NET Infect-ERA CampyRNA and the FCT R&D grant (#POCI-01-0145-FEDER-029999 ). Publisher Copyright: © 2018 Elsevier Ltd

PY - 2019/3

Y1 - 2019/3

N2 - MicroRNAs are a class of small noncoding RNAs that act as major post-transcriptional regulators of gene expression. They are currently recognized for their important role in the intricate interaction between host and bacterial pathogens, either as part of the host immune response to neutralize infection, or as a molecular strategy employed by bacteria to hijack host pathways for their own benefit. Here, we summarize recent advances on the function of miRNAs during infection of mammalian hosts by bacterial pathogens, highlighting key cellular pathways. In addition, we discuss emerging themes in this field, including the participation of miRNAs in host–microbiota crosstalk and cell-to-cell communication.

AB - MicroRNAs are a class of small noncoding RNAs that act as major post-transcriptional regulators of gene expression. They are currently recognized for their important role in the intricate interaction between host and bacterial pathogens, either as part of the host immune response to neutralize infection, or as a molecular strategy employed by bacteria to hijack host pathways for their own benefit. Here, we summarize recent advances on the function of miRNAs during infection of mammalian hosts by bacterial pathogens, highlighting key cellular pathways. In addition, we discuss emerging themes in this field, including the participation of miRNAs in host–microbiota crosstalk and cell-to-cell communication.

KW - bacterial pathogen

KW - cell-to-cell communication

KW - host–pathogen interaction

KW - microbiota

KW - microRNA

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U2 - 10.1016/j.tim.2018.10.011

DO - 10.1016/j.tim.2018.10.011

M3 - Review article

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AN - SCOPUS:85057054669

SN - 0966-842X

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JO - Trends in Microbiology

JF - Trends in Microbiology

IS - 3

ER -

MicroRNAs at the Host–Bacteria Interface: Host Defense or Bacterial Offense

Abstract

Keywords

UN SDGs

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