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MicroRNAs in Cardiovascular Disease

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)2577-2584
Number of pages8
JournalJournal of the American College of Cardiology
Volume68
Issue number23
Early online date5 Dec 2016
DOIs
Accepted/In press16 Sep 2016
E-pub ahead of print5 Dec 2016
Published13 Dec 2016

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King's Authors

Abstract

Micro-ribonucleic acids (miRNAs) are in the spotlight as post-transcriptional regulators of gene expression. More than 1,000 miRNAs are encoded in the human genome. In this review, we provide an introduction to miRNA biology and research methodology, and highlight advances in cardiovascular research to date. This includes the potential of miRNAs as therapeutic targets in cardiac and vascular disease, and their use as novel biomarkers. Although some miRNA therapies are already undergoing clinical evaluation, we stress the importance of integrating current knowledge of miRNA biology into a systemic context. Discovery studies focus on miRNA effects within one specific organ, whereas the expression of most miRNAs is not restricted to a single tissue. Because most miRNA-based therapies act systemically, this may preclude widespread clinical use. The development of more targeted interventions will bolster well-informed clinical applications, increasing the chances of success and minimizing the risk of setbacks for miRNA-based therapeutics.

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