MicroRNAs in the interaction between host and bacterial pathogens

Claire Maudet; Miguel Mano; Ana Eulalio

doi:10.1016/j.febslet.2014.08.002

MicroRNAs in the interaction between host and bacterial pathogens

Claire Maudet, Miguel Mano, Ana Eulalio^*

^*Corresponding author for this work

Cardiovascular Sciences

Research output: Contribution to journal › Review article › peer-review

137 Citations (Scopus)

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs with a central role in the post-transcriptional control of gene expression, that have been implicated in a wide-range of biological processes. Regulation of miRNA expression is increasingly recognized as a crucial part of the host response to infection by bacterial pathogens, as well as a novel molecular strategy exploited by bacteria to manipulate host cell pathways. Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.

Original language	English
Pages (from-to)	4140-4147
Number of pages	8
Journal	FEBS Letters
Volume	588
Issue number	22
DOIs	https://doi.org/10.1016/j.febslet.2014.08.002
Publication status	Published - 17 Nov 2014

Keywords

Bacterial pathogens
Gut microbiota
Host response
MicroRNAs

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10.1016/j.febslet.2014.08.002

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title = "MicroRNAs in the interaction between host and bacterial pathogens",

abstract = "MicroRNAs (miRNAs) are small non-coding RNAs with a central role in the post-transcriptional control of gene expression, that have been implicated in a wide-range of biological processes. Regulation of miRNA expression is increasingly recognized as a crucial part of the host response to infection by bacterial pathogens, as well as a novel molecular strategy exploited by bacteria to manipulate host cell pathways. Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.",

keywords = "Bacterial pathogens, Gut microbiota, Host response, MicroRNAs",

author = "Claire Maudet and Miguel Mano and Ana Eulalio",

note = "Funding Information: The authors are grateful to Dr. Stan Gorski for critical reading and editing of the manuscript. M.M is supported by the FIRB RBAP11Z4Z9 project from the Ministero dell{\textquoteright}Istruzione, dell{\textquoteright}Universit{\`a} e della Ricerca (MIUR), Italy and the FCT Investigator Programme IF/00694/2013, Funda{\c c}{\~a}o para a Ci{\^e}ncia e a Tecnologia (FCT), Portugal. Work at the Eulalio lab is supported by the Bavarian Ministry of Sciences, Research and the Arts in the framework of the Bavarian Molecular Biosystems Research Network (BioSysNet), DFG project BR 4837/1-1 and the FEBS Young Investigator Award to A.E. Publisher Copyright: {\textcopyright} 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.",

year = "2014",

month = nov,

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doi = "10.1016/j.febslet.2014.08.002",

language = "English",

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AU - Maudet, Claire

AU - Mano, Miguel

AU - Eulalio, Ana

N1 - Funding Information: The authors are grateful to Dr. Stan Gorski for critical reading and editing of the manuscript. M.M is supported by the FIRB RBAP11Z4Z9 project from the Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR), Italy and the FCT Investigator Programme IF/00694/2013, Fundação para a Ciência e a Tecnologia (FCT), Portugal. Work at the Eulalio lab is supported by the Bavarian Ministry of Sciences, Research and the Arts in the framework of the Bavarian Molecular Biosystems Research Network (BioSysNet), DFG project BR 4837/1-1 and the FEBS Young Investigator Award to A.E. Publisher Copyright: © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

PY - 2014/11/17

Y1 - 2014/11/17

N2 - MicroRNAs (miRNAs) are small non-coding RNAs with a central role in the post-transcriptional control of gene expression, that have been implicated in a wide-range of biological processes. Regulation of miRNA expression is increasingly recognized as a crucial part of the host response to infection by bacterial pathogens, as well as a novel molecular strategy exploited by bacteria to manipulate host cell pathways. Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.

AB - MicroRNAs (miRNAs) are small non-coding RNAs with a central role in the post-transcriptional control of gene expression, that have been implicated in a wide-range of biological processes. Regulation of miRNA expression is increasingly recognized as a crucial part of the host response to infection by bacterial pathogens, as well as a novel molecular strategy exploited by bacteria to manipulate host cell pathways. Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.

KW - Bacterial pathogens

KW - Gut microbiota

KW - Host response

KW - MicroRNAs

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DO - 10.1016/j.febslet.2014.08.002

M3 - Review article

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VL - 588

SP - 4140

EP - 4147

JO - FEBS Letters

JF - FEBS Letters

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ER -

MicroRNAs in the interaction between host and bacterial pathogens

Abstract

Keywords

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