Abstract
The study of normal retinal physiology and its perturbations in disease is fundamental in the development of novel therapeutic strategies to treat pathological conditions that affect normal sight. Recent findings suggest an emerging role for microRNAs (miRNAs) during development of the retina and the functionality of visual circuits. This chapter describes the impact and roles of miRNAs during retinal development and the establishment of visual connectivity and function. It focuses on their potential roles in regenerative medicine, highlighting recent findings in retinal gene therapy and retinal cell transplantation.
Original language | English |
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Title of host publication | MicroRNA in Regenerative Medicine |
Publisher | Elsevier Inc. |
Pages | 489-514 |
Number of pages | 26 |
ISBN (Electronic) | 9780124058583 |
ISBN (Print) | 9780124055445 |
DOIs | |
Publication status | Published - 23 Dec 2014 |
Keywords
- Cell reprogramming
- Dicer
- Eye
- Gene targeting
- MicroRNA
- Neurons
- Retina
- Retinal diseases