MicroRNAs in the Retina and in Visual Connectivity

Nicola Antonio Maiorano*, Robert Hindges

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

The study of normal retinal physiology and its perturbations in disease is fundamental in the development of novel therapeutic strategies to treat pathological conditions that affect normal sight. Recent findings suggest an emerging role for microRNAs (miRNAs) during development of the retina and the functionality of visual circuits. This chapter describes the impact and roles of miRNAs during retinal development and the establishment of visual connectivity and function. It focuses on their potential roles in regenerative medicine, highlighting recent findings in retinal gene therapy and retinal cell transplantation.

Original languageEnglish
Title of host publicationMicroRNA in Regenerative Medicine
PublisherElsevier Inc.
Pages489-514
Number of pages26
ISBN (Electronic)9780124058583
ISBN (Print)9780124055445
DOIs
Publication statusPublished - 23 Dec 2014

Keywords

  • Cell reprogramming
  • Dicer
  • Eye
  • Gene targeting
  • MicroRNA
  • Neurons
  • Retina
  • Retinal diseases

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