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Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study

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Microstructural white matter tract alteration in Prader-Willi syndrome : A diffusion tensor imaging study. / Rice, Lauren J.; Lagopoulos, Jim; Brammer, Michael; Einfeld, Stewart L.

In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, Vol. 175, No. 3, 01.09.2017, p. 362-367.

Research output: Contribution to journalArticle

Harvard

Rice, LJ, Lagopoulos, J, Brammer, M & Einfeld, SL 2017, 'Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study', American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, vol. 175, no. 3, pp. 362-367. https://doi.org/10.1002/ajmg.c.31572

APA

Rice, L. J., Lagopoulos, J., Brammer, M., & Einfeld, S. L. (2017). Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics, 175(3), 362-367. https://doi.org/10.1002/ajmg.c.31572

Vancouver

Rice LJ, Lagopoulos J, Brammer M, Einfeld SL. Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study. American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 2017 Sep 1;175(3):362-367. https://doi.org/10.1002/ajmg.c.31572

Author

Rice, Lauren J. ; Lagopoulos, Jim ; Brammer, Michael ; Einfeld, Stewart L. / Microstructural white matter tract alteration in Prader-Willi syndrome : A diffusion tensor imaging study. In: American Journal of Medical Genetics, Part C: Seminars in Medical Genetics. 2017 ; Vol. 175, No. 3. pp. 362-367.

Bibtex Download

@article{a5b91e682a2b4d108e8a4a015ea983df,
title = "Microstructural white matter tract alteration in Prader-Willi syndrome: A diffusion tensor imaging study",
abstract = "Prader-Willi Syndrome (PWS) is a genetic disorder characterized by infantile hypotonia, hyperphagia, hypogonadism, growth hormone deficiency, intellectual disability, and severe emotional and behavioral problems. The brain mechanisms that underpin these disturbances are unknown. Diffusion tensor imaging (DTI) enables in vivo investigation of the microstructural integrity of white matter pathways. To date, only one study has used DTI to examine white matter alterations in PWS. However, that study used selected regions of interest, rather than a whole brain analysis. In the present study, we used diffusion tensor and magnetic resonance (T 1-weighted) imaging to examine microstructural white matter changes in 15 individuals with PWS (17–30 years) and 15 age-and-gender-matched controls. Whole-brain voxel-wise statistical analysis of FA was carried out using tract-based spatial statistics (TBSS). Significantly decreased fractional anisotropy was found localized to the left hemisphere in individuals with PWS within the splenium of the corpus callosum, the internal capsule including the posterior thalamic radiation and the inferior frontal occipital fasciculus (IFOF). Reduced integrity of these white matter pathways in individuals with PWS may relate to orientating attention, emotion recognition, semantic processing, and sensorimotor dysfunction.",
keywords = "diffusion tensor imaging, fractional anisotropy, Prade-Willi syndrome, PWS, white matter",
author = "Rice, {Lauren J.} and Jim Lagopoulos and Michael Brammer and Einfeld, {Stewart L.}",
year = "2017",
month = "9",
day = "1",
doi = "10.1002/ajmg.c.31572",
language = "English",
volume = "175",
pages = "362--367",
journal = "American Journal of Medical Genetics. Part C: Seminars in Medical Genetics",
issn = "1552-4868",
publisher = "Wiley-Liss Inc.",
number = "3",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Microstructural white matter tract alteration in Prader-Willi syndrome

T2 - A diffusion tensor imaging study

AU - Rice, Lauren J.

AU - Lagopoulos, Jim

AU - Brammer, Michael

AU - Einfeld, Stewart L.

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Prader-Willi Syndrome (PWS) is a genetic disorder characterized by infantile hypotonia, hyperphagia, hypogonadism, growth hormone deficiency, intellectual disability, and severe emotional and behavioral problems. The brain mechanisms that underpin these disturbances are unknown. Diffusion tensor imaging (DTI) enables in vivo investigation of the microstructural integrity of white matter pathways. To date, only one study has used DTI to examine white matter alterations in PWS. However, that study used selected regions of interest, rather than a whole brain analysis. In the present study, we used diffusion tensor and magnetic resonance (T 1-weighted) imaging to examine microstructural white matter changes in 15 individuals with PWS (17–30 years) and 15 age-and-gender-matched controls. Whole-brain voxel-wise statistical analysis of FA was carried out using tract-based spatial statistics (TBSS). Significantly decreased fractional anisotropy was found localized to the left hemisphere in individuals with PWS within the splenium of the corpus callosum, the internal capsule including the posterior thalamic radiation and the inferior frontal occipital fasciculus (IFOF). Reduced integrity of these white matter pathways in individuals with PWS may relate to orientating attention, emotion recognition, semantic processing, and sensorimotor dysfunction.

AB - Prader-Willi Syndrome (PWS) is a genetic disorder characterized by infantile hypotonia, hyperphagia, hypogonadism, growth hormone deficiency, intellectual disability, and severe emotional and behavioral problems. The brain mechanisms that underpin these disturbances are unknown. Diffusion tensor imaging (DTI) enables in vivo investigation of the microstructural integrity of white matter pathways. To date, only one study has used DTI to examine white matter alterations in PWS. However, that study used selected regions of interest, rather than a whole brain analysis. In the present study, we used diffusion tensor and magnetic resonance (T 1-weighted) imaging to examine microstructural white matter changes in 15 individuals with PWS (17–30 years) and 15 age-and-gender-matched controls. Whole-brain voxel-wise statistical analysis of FA was carried out using tract-based spatial statistics (TBSS). Significantly decreased fractional anisotropy was found localized to the left hemisphere in individuals with PWS within the splenium of the corpus callosum, the internal capsule including the posterior thalamic radiation and the inferior frontal occipital fasciculus (IFOF). Reduced integrity of these white matter pathways in individuals with PWS may relate to orientating attention, emotion recognition, semantic processing, and sensorimotor dysfunction.

KW - diffusion tensor imaging

KW - fractional anisotropy

KW - Prade-Willi syndrome

KW - PWS

KW - white matter

UR - http://www.scopus.com/inward/record.url?scp=85028409714&partnerID=8YFLogxK

U2 - 10.1002/ajmg.c.31572

DO - 10.1002/ajmg.c.31572

M3 - Article

C2 - 28834083

AN - SCOPUS:85028409714

VL - 175

SP - 362

EP - 367

JO - American Journal of Medical Genetics. Part C: Seminars in Medical Genetics

JF - American Journal of Medical Genetics. Part C: Seminars in Medical Genetics

SN - 1552-4868

IS - 3

ER -

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