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Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder

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Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder. / Shephard, Elizabeth; Milosavljevic, Bosiljka; Pasco, Gregory; Jones, Emily; Gliga, Teodora; Happe, Francesca Gabrielle Elizabeth; Johnson, Mark H.; Charman, Tony.

In: Autism research, 29.11.2016.

Research output: Contribution to journalArticle

Harvard

Shephard, E, Milosavljevic, B, Pasco, G, Jones, E, Gliga, T, Happe, FGE, Johnson, MH & Charman, T 2016, 'Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder', Autism research. https://doi.org/10.1002/aur.1733

APA

Shephard, E., Milosavljevic, B., Pasco, G., Jones, E., Gliga, T., Happe, F. G. E., Johnson, M. H., & Charman, T. (2016). Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder. Autism research. https://doi.org/10.1002/aur.1733

Vancouver

Shephard E, Milosavljevic B, Pasco G, Jones E, Gliga T, Happe FGE et al. Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder. Autism research. 2016 Nov 29. https://doi.org/10.1002/aur.1733

Author

Shephard, Elizabeth ; Milosavljevic, Bosiljka ; Pasco, Gregory ; Jones, Emily ; Gliga, Teodora ; Happe, Francesca Gabrielle Elizabeth ; Johnson, Mark H. ; Charman, Tony. / Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder. In: Autism research. 2016.

Bibtex Download

@article{08b9a7d33479422793d211d454b6bf1c,
title = "Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder",
abstract = "Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling withan ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-riskinfants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age7, high-risk children without ASD, and low-risk control children. Diagnostic stability between 3 and 7 years was moder-ate. High-risk siblings with ASD showed elevated levels of ADHD and anxiety symptoms and lower adaptive behaviourthan low-risk control children. High-risk siblings without ASD had higher repetitive behaviours, lower adaptive func-tioning, and elevated scores on one anxiety subscale (Separation Anxiety) compared to low-risk controls. The findingsindicate that the difficulties experienced by high-risk siblings at school age extend beyond ASD symptoms. Betterunderstanding of these difficulties may improve models of the development of co-occurring problems seen in childrenwith ASD.",
author = "Elizabeth Shephard and Bosiljka Milosavljevic and Gregory Pasco and Emily Jones and Teodora Gliga and Happe, {Francesca Gabrielle Elizabeth} and Johnson, {Mark H.} and Tony Charman",
year = "2016",
month = nov,
day = "29",
doi = "10.1002/aur.1733",
language = "English",
journal = "Autism research",
issn = "1939-3792",
publisher = "John Wiley & Sons, Ltd",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Mid-Childhood Outcomes of Infant Siblings at Familial High-Risk of Autism Spectrum Disorder

AU - Shephard, Elizabeth

AU - Milosavljevic, Bosiljka

AU - Pasco, Gregory

AU - Jones, Emily

AU - Gliga, Teodora

AU - Happe, Francesca Gabrielle Elizabeth

AU - Johnson, Mark H.

AU - Charman, Tony

PY - 2016/11/29

Y1 - 2016/11/29

N2 - Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling withan ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-riskinfants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age7, high-risk children without ASD, and low-risk control children. Diagnostic stability between 3 and 7 years was moder-ate. High-risk siblings with ASD showed elevated levels of ADHD and anxiety symptoms and lower adaptive behaviourthan low-risk control children. High-risk siblings without ASD had higher repetitive behaviours, lower adaptive func-tioning, and elevated scores on one anxiety subscale (Separation Anxiety) compared to low-risk controls. The findingsindicate that the difficulties experienced by high-risk siblings at school age extend beyond ASD symptoms. Betterunderstanding of these difficulties may improve models of the development of co-occurring problems seen in childrenwith ASD.

AB - Almost one-in-five infants at high familial risk for autism spectrum disorder (ASD), due to having an older sibling withan ASD diagnosis, develop ASD themselves by age 3 years. Less is known about the longer-term outcomes of high-riskinfants. To address this issue, we examined symptoms of ASD and associated developmental conditions (attention-deficit/hyperactivity disorder (ADHD); anxiety), language, IQ, and adaptive behaviour at age 7 years in high- and low-risk children studied from infancy. We compared outcomes between high-risk children who met criteria for ASD at age7, high-risk children without ASD, and low-risk control children. Diagnostic stability between 3 and 7 years was moder-ate. High-risk siblings with ASD showed elevated levels of ADHD and anxiety symptoms and lower adaptive behaviourthan low-risk control children. High-risk siblings without ASD had higher repetitive behaviours, lower adaptive func-tioning, and elevated scores on one anxiety subscale (Separation Anxiety) compared to low-risk controls. The findingsindicate that the difficulties experienced by high-risk siblings at school age extend beyond ASD symptoms. Betterunderstanding of these difficulties may improve models of the development of co-occurring problems seen in childrenwith ASD.

U2 - 10.1002/aur.1733

DO - 10.1002/aur.1733

M3 - Article

JO - Autism research

JF - Autism research

SN - 1939-3792

ER -

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