Mind and skin: Exploring the links between inflammation, sleep disturbance and neurocognitive function in patients with atopic dermatitis

TY - JOUR

T1 - Mind and skin

T2 - Exploring the links between inflammation, sleep disturbance and neurocognitive function in patients with atopic dermatitis

AU - Cameron, Shona

AU - Donnelly, Ali

AU - Broderick, Conor

AU - Arichi, Tomoki

AU - Bartsch, Ullrich

AU - Dazzan, Paola

AU - Elbeling, Jesper

AU - Godfrey, Emma

AU - Gringras, Paul

AU - Heathcote, Lauren C.

AU - Joseph, Desaline

AU - Wood, Tobias C.

AU - Pariante, Carmine

AU - Rubia, Katya

AU - Flohr, Carsten

N1 - Publisher Copyright: © 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

PY - 2024/1

Y1 - 2024/1

N2 - Atopic dermatitis (AD) is a chronic, pruritic and inflammatory, dry skin condition with many known comorbidities. These include airway disease, food allergies, atopic eye disease and autoimmune conditions. Furthermore, there is often significant sleep disturbance as well as increased psychological distress and mental health problems. Severe AD therefore often has a significant impact on the quality of life of both patients and their families. In this review we discuss recent findings on the putative links between AD, its association with itch, sleep disturbance and neuropsychiatric morbidity, including the role of inflammation in these conditions. Itch was thought to predominantly drive sleep disruption in AD. We now understand changes in sleep influence immune cell distribution and the associated inflammatory cytokines, which suggests a bidirectional relationship between AD and sleep. We also increasingly recognize inflammation as a key driver in psychological symptoms and disorders. The link between cutaneous, systemic and possible brain inflammation could at least in part be driven by the sleep deprivation and itch-driven neuronal proliferation seen in AD.

AB - Atopic dermatitis (AD) is a chronic, pruritic and inflammatory, dry skin condition with many known comorbidities. These include airway disease, food allergies, atopic eye disease and autoimmune conditions. Furthermore, there is often significant sleep disturbance as well as increased psychological distress and mental health problems. Severe AD therefore often has a significant impact on the quality of life of both patients and their families. In this review we discuss recent findings on the putative links between AD, its association with itch, sleep disturbance and neuropsychiatric morbidity, including the role of inflammation in these conditions. Itch was thought to predominantly drive sleep disruption in AD. We now understand changes in sleep influence immune cell distribution and the associated inflammatory cytokines, which suggests a bidirectional relationship between AD and sleep. We also increasingly recognize inflammation as a key driver in psychological symptoms and disorders. The link between cutaneous, systemic and possible brain inflammation could at least in part be driven by the sleep deprivation and itch-driven neuronal proliferation seen in AD.

KW - atopic dermatitis

KW - cognitive dysfunction

KW - inflammation

KW - quality-of-life

KW - sleep disruption

UR - http://www.scopus.com/inward/record.url?scp=85165514749&partnerID=8YFLogxK

U2 - 10.1111/all.15818

DO - 10.1111/all.15818

M3 - Review article

C2 - 37469218

AN - SCOPUS:85165514749

SN - 0105-4538

VL - 79

SP - 26

EP - 36

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 1

ER -