Minimum Information About a Spinal Cord Injury Experiment (MIASCI): a proposed reporting standard for spinal cord injury experiments

Vance P Lemmon, Adam R Ferguson, Phillip G Popovich, Xiao-Ming Xu, Diane M Snow, Michihiro Igarashi, Christine E Beattie, John L Bixby, Miasci Consortium, Saminda W Abeyruwan, Michael S Beattie, John Bethea, Frank Bradke, Jacqueline C Bresnahan, Mary B Bunge, Alison Callahan, Sam David, Sarah Alison Dunlop, James Fawcett, Michael FehlingsItzhak Fischer, Roman J Giger, Yoshio Goshima, Barbara Grimpe, Theo Hagg, Edward D Hall, Benjamin J Harrison, Alan R Harvey, Cheng He, Zhigang He, Tatsumi Hirata, Ahmet Hoke, Claire E Hulsebosch, Andres Hurtado, Anjana Jain, Ken Kadoya, Hiroyuki Kamiguchi, Mineko Kengaku, Jeffery D Kocsis, Brian K Kwon, Jae K Lee, Daniel J Liebl, Shao-Jun Liu, Laura A Lowery, Shweta Mandrekar-Colucci, John H Martin, Carol A Mason, Dana M McTigue, Nassir Mokarram, Lawrence D Moon, Hans W Muller, Takeshi Nakamura, Takashi Namba, Mariko Nishibe, Izumi Oinuma, Martin Oudega, David E Pleasure, Geoffrey Raisman, Matthew N Rasband, Paul J Reier, Miguel Santiago-Medina, Jan M Schwab, Martin E Schwab, Yohei Shinmyo, Jerry Silver, George M Smith, Kwok-Fai So, Michael V Sofroniew, Stephen M Strittmatter, Mark H Tuszynski, Jeffery L Twiss, Ubbo Visser, Trent A Watkins, Wutian Wu, Sung Ok Yoon, Michisuke Yuzaki, Binhai Zheng, Fengquan Zhou, Yimin Zou

Research output: Contribution to journalArticlepeer-review

65 Citations (Scopus)


The lack of reproducibility in many areas of experimental science has a number of causes, including a lack of transparency and precision in the description of experimental approaches. This has far-reaching consequences, including wasted resources and slowing of progress. Additionally, the large number of laboratories around the world publishing papers on a given topic make it difficult, if not impossible, for individual researchers to read all of the relevant literature. Consequently, centralized databases are needed to facilitate the generation of new hypotheses for testing. One strategy to improve transparency in experimental description, and to allow the development of frameworks for computer-readable knowledge repositories, is the adoption of uniform reporting standards, such as common data elements (data elements used in multiple clinical studies) and minimum information standards. This paper describes a minimum information standard for spinal cord injury (SCI) experiments, its major elements and the approaches used to develop it. Transparent reporting standards for experiments using animal models of human SCI aim to reduce inherent bias and increase experimental value.
Original languageEnglish
JournalJournal of Neurotrauma
Publication statusE-pub ahead of print - 2014


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