MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

Chao Zou, Qing Xu, Feng Mao, Dan Li, Chuanxiu Bian, Ling-Zhi Liu, Yue Jiang, Xiaona Chen, Yanting Qi, Xiaolong Zhang, Xuejing Wang, Qiang Sun, Hsiang-Fu Kung, Marie C. Lin, Andreas Dress, Fiona Wardle, Bing-Hua Jiang*, Lihui Lai

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

115 Citations (Scopus)

Abstract

MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.

Original languageEnglish
Pages (from-to)2137-2145
Number of pages9
JournalCELL CYCLE
Volume11
Issue number11
DOIs
Publication statusPublished - 1 Jun 2012

Keywords

  • miR-145
  • N-RAS
  • VEGF-A
  • angiogenesis
  • breast cancer
  • HUMAN BREAST-CANCER
  • INSULIN-RECEPTOR SUBSTRATE-1
  • SQUAMOUS-CELL CARCINOMA
  • ACTIVATED MICRORNA
  • ENDOTHELIAL-CELLS
  • BLADDER-CANCER
  • STEM-CELLS
  • EXPRESSION
  • OVEREXPRESSION
  • METASTASIS

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