MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

Chao Zou; Qing Xu; Feng Mao; Dan Li; Chuanxiu Bian; Ling-Zhi Liu; Yue Jiang; Xiaona Chen; Yanting Qi; Xiaolong Zhang; Xuejing Wang; Qiang Sun; Hsiang-Fu Kung; Marie C. Lin; Andreas Dress; Fiona Wardle; Bing-Hua Jiang; Lihui Lai

doi:10.4161/cc.20598

MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

Chao Zou, Qing Xu, Feng Mao, Dan Li, Chuanxiu Bian, Ling-Zhi Liu, Yue Jiang, Xiaona Chen, Yanting Qi, Xiaolong Zhang, Xuejing Wang, Qiang Sun, Hsiang-Fu Kung, Marie C. Lin, Andreas Dress, Fiona Wardle, Bing-Hua Jiang^*, Lihui Lai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

121 Citations (Scopus)

Abstract

MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.

Original language	English
Pages (from-to)	2137-2145
Number of pages	9
Journal	CELL CYCLE
Volume	11
Issue number	11
DOIs	https://doi.org/10.4161/cc.20598
Publication status	Published - 1 Jun 2012

Keywords

miR-145
N-RAS
VEGF-A
angiogenesis
breast cancer
HUMAN BREAST-CANCER
INSULIN-RECEPTOR SUBSTRATE-1
SQUAMOUS-CELL CARCINOMA
ACTIVATED MICRORNA
ENDOTHELIAL-CELLS
BLADDER-CANCER
STEM-CELLS
EXPRESSION
OVEREXPRESSION
METASTASIS

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/cc.20598

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title = "MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF",

abstract = "MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.",

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author = "Chao Zou and Qing Xu and Feng Mao and Dan Li and Chuanxiu Bian and Ling-Zhi Liu and Yue Jiang and Xiaona Chen and Yanting Qi and Xiaolong Zhang and Xuejing Wang and Qiang Sun and Hsiang-Fu Kung and Lin, {Marie C.} and Andreas Dress and Fiona Wardle and Bing-Hua Jiang and Lihui Lai",

year = "2012",

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doi = "10.4161/cc.20598",

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TY - JOUR

T1 - MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

AU - Zou, Chao

AU - Xu, Qing

AU - Mao, Feng

AU - Li, Dan

AU - Bian, Chuanxiu

AU - Liu, Ling-Zhi

AU - Jiang, Yue

AU - Chen, Xiaona

AU - Qi, Yanting

AU - Zhang, Xiaolong

AU - Wang, Xuejing

AU - Sun, Qiang

AU - Kung, Hsiang-Fu

AU - Lin, Marie C.

AU - Dress, Andreas

AU - Wardle, Fiona

AU - Jiang, Bing-Hua

AU - Lai, Lihui

PY - 2012/6/1

Y1 - 2012/6/1

N2 - MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.

AB - MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role in tumor angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated in breast cancer tissues by using 106 cases of normal and cancer tissues as well as in breast cancer cells. MiR-145 exhibited inhibitory role in tumor angiogenesis, cell growth and invasion and tumor growth through the post-transcriptional regulation of the novel targets N-RAS and VEGF-A. In addition, we provide evidence that the expression levels of miR-145 correlate inversely with malignancy stages of breast tumors, although there is no association between miR-145 levels and hormone receptor levels in breast cancer. Taken together, these results demonstrate that miR-145 plays important inhibitory role in breast cancer malignancy by targeting N-RAS and VEGF-A, which may be potential therapeutic and diagnostic targets.

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KW - N-RAS

KW - VEGF-A

KW - angiogenesis

KW - breast cancer

KW - HUMAN BREAST-CANCER

KW - INSULIN-RECEPTOR SUBSTRATE-1

KW - SQUAMOUS-CELL CARCINOMA

KW - ACTIVATED MICRORNA

KW - ENDOTHELIAL-CELLS

KW - BLADDER-CANCER

KW - STEM-CELLS

KW - EXPRESSION

KW - OVEREXPRESSION

KW - METASTASIS

U2 - 10.4161/cc.20598

DO - 10.4161/cc.20598

M3 - Article

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EP - 2145

JO - CELL CYCLE

JF - CELL CYCLE

IS - 11

ER -

MiR-145 inhibits tumor angiogenesis and growth by N-RAS and VEGF

Abstract

Keywords

UN SDGs

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