miR-195 inhibits tumor growth and angiogenesis through modulating IRS1 in breast cancer

Yilin Wang, Xiaolong Zhang, Chao Zou, Hsiang-Fu Kung, Marie C. Lin, Andreas Dress, Fiona Wardle, Bing-Hua Jiang, Lihui Lai

Research output: Contribution to journalArticlepeer-review

70 Citations (Scopus)


Angiogenesis has been found as an attractive target for drug therapy as it is necessary for tumor growth. Accumulating evidences show that microRNAs (miRNAs), which are a group of highly conserved, single-stranded, short non-coding RNAs, play important roles through directly targeting angiogenic factors and protein kinases. The purpose of this study is to investigate the role of miR-195 in breast cancer development and angiogenesis through targeting IRS1. We show that miR-195 is inversely related with Insulin receptor substrate 1 (IRS1) in both breast cancer cells and breast cancer tissues. Induction of miR-195 could suppress IRS1 protein expression through binding to its 3′UTR regions either by transfection with miR-195 oligo or by infection with lentivirus encoding miR-195 gene. Moreover, re-expression of IRS1 reverses miR-195-mediated repression of tumor cell growth and miR-195 inhibits tumor angiogenesis through suppressing IRS1-VEGF axis. These data suggest that miR-195 mimics are potential therapeutic agents for breast cancer diagnose.
Original languageEnglish
Pages (from-to)95-101
Number of pages7
JournalBiomedicine and Pharmacotherapy
Early online date17 Mar 2016
Publication statusPublished - May 2016


  • MiR-195
  • Insulin receptor substrate 1
  • Breast cancer
  • Angiogenesis


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