Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

Claire Thornton; Adam Jones; Syam Nair; Afra Aabdien; Carina Mallard; Henrik Hagberg

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

Claire Thornton, Adam Jones, Syam Nair, Afra Aabdien, Carina Mallard, Henrik Hagberg

Sahlgrenska University Hospital

Research output: Contribution to journal › Review article › peer-review

44 Citations (Scopus)

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Abstract

Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occurs. Currently, there are limited treatment options and additional therapies are urgently required. Mitochondrial dysfunction acts as a focal point in injury development in the immature brain. Not only do mitochondria become permeabilised, but recent findings implicate perturbations in mitochondrial dynamics (fission, fusion), mitophagy and biogenesis. Mitoprotective therapies may therefore offer a new avenue of intervention for babies who suffer life-long disabilities due to birth asphyxia.

Original language	English
Journal	FEBS Letters
Early online date	25 Dec 2017
Publication status	E-pub ahead of print - 25 Dec 2017

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Mitochondrial dynamics, mitophagy and_THORNTON_Publishedonline25December2017_GREEN AAMAccepted author manuscript, 1.24 MBLicence: Unspecified

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title = "Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury",

abstract = "Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occurs. Currently, there are limited treatment options and additional therapies are urgently required. Mitochondrial dysfunction acts as a focal point in injury development in the immature brain. Not only do mitochondria become permeabilised, but recent findings implicate perturbations in mitochondrial dynamics (fission, fusion), mitophagy and biogenesis. Mitoprotective therapies may therefore offer a new avenue of intervention for babies who suffer life-long disabilities due to birth asphyxia.",

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T1 - Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

AU - Thornton, Claire

AU - Jones, Adam

AU - Nair, Syam

AU - Aabdien, Afra

AU - Mallard, Carina

AU - Hagberg, Henrik

PY - 2017/12/25

Y1 - 2017/12/25

N2 - Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occurs. Currently, there are limited treatment options and additional therapies are urgently required. Mitochondrial dysfunction acts as a focal point in injury development in the immature brain. Not only do mitochondria become permeabilised, but recent findings implicate perturbations in mitochondrial dynamics (fission, fusion), mitophagy and biogenesis. Mitoprotective therapies may therefore offer a new avenue of intervention for babies who suffer life-long disabilities due to birth asphyxia.

AB - Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occurs. Currently, there are limited treatment options and additional therapies are urgently required. Mitochondrial dysfunction acts as a focal point in injury development in the immature brain. Not only do mitochondria become permeabilised, but recent findings implicate perturbations in mitochondrial dynamics (fission, fusion), mitophagy and biogenesis. Mitoprotective therapies may therefore offer a new avenue of intervention for babies who suffer life-long disabilities due to birth asphyxia.

M3 - Review article

SN - 0014-5793

JO - FEBS Letters

JF - FEBS Letters

ER -

Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

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