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Mitochondrial dynamics, mitophagy and biogenesis in neonatal hypoxic-ischaemic brain injury

Research output: Contribution to journalReview article

Claire Thornton, Adam Jones, Syam Nair, Afra Aabdien, Carina Mallard, Henrik Hagberg

Original languageEnglish
JournalFEBS Letters
Early online date25 Dec 2017
Publication statusE-pub ahead of print - 25 Dec 2017

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Abstract

Hypoxic-ischaemic encephalopathy, resulting from asphyxia during birth, affects 2-3 in every 1000 term infants and depending on severity, brings about life-changing neurological consequences or death. This hypoxic-ischaemia (HI) results in a delayed neural energy failure during which the majority of brain injury occurs. Currently, there are limited treatment options and additional therapies are urgently required. Mitochondrial dysfunction acts as a focal point in injury development in the immature brain. Not only do mitochondria become permeabilised, but recent findings implicate perturbations in mitochondrial dynamics (fission, fusion), mitophagy and biogenesis. Mitoprotective therapies may therefore offer a new avenue of intervention for babies who suffer life-long disabilities due to birth asphyxia.

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