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Mixing and matching nuclear envelope remodeling and spindle assembly strategies in the evolution of mitosis

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)43-50
Number of pages8
JournalCurrent Opinion in Cell Biology
Early online date7 Apr 2016
Accepted/In press24 Mar 2016
E-pub ahead of print7 Apr 2016
PublishedAug 2016


King's Authors


In eukaryotes, cellular genome is enclosed inside a membrane-bound organelle called the nucleus. The nucleus compartmentalizes genome replication, repair and expression, keeping these activities separated from protein synthesis and other metabolic processes. Each proliferative division, the duplicated chromosomes must be equipartitioned between the daughter cells and this requires precise coordination between assembly of the microtubule-based mitotic spindle and nuclear remodeling. Here we review a surprising variety of strategies used by modern eukaryotes to manage these processes and discuss possible mechanisms that might have led to the emergence of this diversity in evolution.

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