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Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case-control MRI studies

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Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder : Multimodal meta-analysis of case-control MRI studies. / Picó-Pérez, Maria; Moreira, Pedro Silva; de Melo Ferreira, Vanessa; Radua, Joaquim; Mataix-Cols, David; Sousa, Nuno; Soriano-Mas, Carles; Morgado, Pedro.

In: Neuroscience and Biobehavioral Reviews, Vol. 112, 05.2020, p. 83-94.

Research output: Contribution to journalReview article

Harvard

Picó-Pérez, M, Moreira, PS, de Melo Ferreira, V, Radua, J, Mataix-Cols, D, Sousa, N, Soriano-Mas, C & Morgado, P 2020, 'Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case-control MRI studies', Neuroscience and Biobehavioral Reviews, vol. 112, pp. 83-94. https://doi.org/10.1016/j.neubiorev.2020.01.033

APA

Picó-Pérez, M., Moreira, P. S., de Melo Ferreira, V., Radua, J., Mataix-Cols, D., Sousa, N., ... Morgado, P. (2020). Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case-control MRI studies. Neuroscience and Biobehavioral Reviews, 112, 83-94. https://doi.org/10.1016/j.neubiorev.2020.01.033

Vancouver

Picó-Pérez M, Moreira PS, de Melo Ferreira V, Radua J, Mataix-Cols D, Sousa N et al. Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case-control MRI studies. Neuroscience and Biobehavioral Reviews. 2020 May;112:83-94. https://doi.org/10.1016/j.neubiorev.2020.01.033

Author

Picó-Pérez, Maria ; Moreira, Pedro Silva ; de Melo Ferreira, Vanessa ; Radua, Joaquim ; Mataix-Cols, David ; Sousa, Nuno ; Soriano-Mas, Carles ; Morgado, Pedro. / Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder : Multimodal meta-analysis of case-control MRI studies. In: Neuroscience and Biobehavioral Reviews. 2020 ; Vol. 112. pp. 83-94.

Bibtex Download

@article{82846074bfaf4405b53cdff430834dfe,
title = "Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder: Multimodal meta-analysis of case-control MRI studies",
abstract = "Neuroimaging research has shown that patients with obsessive-compulsive disorder (OCD) may present brain structural and functional alterations, but the results across imaging modalities and task paradigms are difficult to reconcile. Are the same brain systems that are structurally different in OCD patients also involved in executive function and emotional processing? To answer this, we conducted separate meta-analyses of voxel-based morphometry studies, executive function functional magnetic resonance imaging (fMRI) studies, and emotional processing fMRI studies. Next, with a multimodal approach (conjunction analysis), we identified the common alterations across meta-analyses. Patients presented increased gray matter volume and hyperactivation in the putamen, but the putamen subregions affected differed depending on the psychological process. Left posterior/dorsal putamen showed hyperactivation during executive processing tasks, while predominantly right anterior/ventral putamen showed hyperactivation during emotional processing tasks. Interestingly, age was significantly associated with increased right putamen volume. Finally, the left dorsolateral prefrontal cortex was hyperactive in both functional domains. Our findings highlight task-specific correlates of brain structure and function in OCD and help integrate a growing literature.",
keywords = "Emotional processing, Executive functioning, Meta-analysis, Obsessive-compulsive disorder, putamen, Voxel-based morphometry",
author = "Maria Pic{\'o}-P{\'e}rez and Moreira, {Pedro Silva} and {de Melo Ferreira}, Vanessa and Joaquim Radua and David Mataix-Cols and Nuno Sousa and Carles Soriano-Mas and Pedro Morgado",
year = "2020",
month = "5",
doi = "10.1016/j.neubiorev.2020.01.033",
language = "English",
volume = "112",
pages = "83--94",
journal = "Neuroscience and Biobehavioral Reviews",
issn = "0149-7634",

}

RIS (suitable for import to EndNote) Download

TY - JOUR

T1 - Modality-specific overlaps in brain structure and function in obsessive-compulsive disorder

T2 - Multimodal meta-analysis of case-control MRI studies

AU - Picó-Pérez, Maria

AU - Moreira, Pedro Silva

AU - de Melo Ferreira, Vanessa

AU - Radua, Joaquim

AU - Mataix-Cols, David

AU - Sousa, Nuno

AU - Soriano-Mas, Carles

AU - Morgado, Pedro

PY - 2020/5

Y1 - 2020/5

N2 - Neuroimaging research has shown that patients with obsessive-compulsive disorder (OCD) may present brain structural and functional alterations, but the results across imaging modalities and task paradigms are difficult to reconcile. Are the same brain systems that are structurally different in OCD patients also involved in executive function and emotional processing? To answer this, we conducted separate meta-analyses of voxel-based morphometry studies, executive function functional magnetic resonance imaging (fMRI) studies, and emotional processing fMRI studies. Next, with a multimodal approach (conjunction analysis), we identified the common alterations across meta-analyses. Patients presented increased gray matter volume and hyperactivation in the putamen, but the putamen subregions affected differed depending on the psychological process. Left posterior/dorsal putamen showed hyperactivation during executive processing tasks, while predominantly right anterior/ventral putamen showed hyperactivation during emotional processing tasks. Interestingly, age was significantly associated with increased right putamen volume. Finally, the left dorsolateral prefrontal cortex was hyperactive in both functional domains. Our findings highlight task-specific correlates of brain structure and function in OCD and help integrate a growing literature.

AB - Neuroimaging research has shown that patients with obsessive-compulsive disorder (OCD) may present brain structural and functional alterations, but the results across imaging modalities and task paradigms are difficult to reconcile. Are the same brain systems that are structurally different in OCD patients also involved in executive function and emotional processing? To answer this, we conducted separate meta-analyses of voxel-based morphometry studies, executive function functional magnetic resonance imaging (fMRI) studies, and emotional processing fMRI studies. Next, with a multimodal approach (conjunction analysis), we identified the common alterations across meta-analyses. Patients presented increased gray matter volume and hyperactivation in the putamen, but the putamen subregions affected differed depending on the psychological process. Left posterior/dorsal putamen showed hyperactivation during executive processing tasks, while predominantly right anterior/ventral putamen showed hyperactivation during emotional processing tasks. Interestingly, age was significantly associated with increased right putamen volume. Finally, the left dorsolateral prefrontal cortex was hyperactive in both functional domains. Our findings highlight task-specific correlates of brain structure and function in OCD and help integrate a growing literature.

KW - Emotional processing

KW - Executive functioning

KW - Meta-analysis

KW - Obsessive-compulsive disorder

KW - putamen

KW - Voxel-based morphometry

UR - http://www.scopus.com/inward/record.url?scp=85078900989&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2020.01.033

DO - 10.1016/j.neubiorev.2020.01.033

M3 - Review article

C2 - 32006553

AN - SCOPUS:85078900989

VL - 112

SP - 83

EP - 94

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -

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