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Mode of iron(iii) chelation by hexadentate hydroxypyridinones

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)5614-5617
Number of pages4
JournalChemical communications (Cambridge, England)
Volume51
Issue number26
DOIs
Publication statusPublished - 4 Apr 2015

King's Authors

Abstract

Tripodal hexadentate hydroxypyridin-4-ones are increasingly utilised as iron(iii) and gallium(iii) ligands, their attachment to proteins being particularly useful for positron emission tomography (PET). A widely studied tripodal ligand NTA(BuHP)<inf>3</inf>, which is reported to form 1:1 iron(iii) and gallium(iii) complexes in aqueous, media forms 2:2 complexes under physiological conditions. This important difference has implications for both iron chelation therapy and PET imaging. This journal is

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