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Model-based indices of early-stage cardiovascular failure and its therapeutic management in Fontan patients

Research output: Chapter in Book/Report/Conference proceedingConference paper

Original languageEnglish
Title of host publicationFunctional Imaging and Modeling of the Heart - 10th International Conference, FIMH 2019, Proceedings
EditorsValéry Ozenne, Edward Vigmond, Yves Coudière, Nejib Zemzemi
Number of pages9
Accepted/In press17 Apr 2019
E-pub ahead of print30 May 2019
Published6 Jun 2019
EventFunctional Imaging and Modeling of Heart 2019 - Bordeaux, France
Duration: 6 Jun 20198 Jun 2019

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume11504 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349


ConferenceFunctional Imaging and Modeling of Heart 2019
Abbreviated titleFIMH2019


King's Authors


Investigating the causes of failure of Fontan circulation in individual patients remains challenging despite detailed combined invasive cardiac catheterisation and magnetic resonance (XMR) exams at rest and during stress. In this work, we use a biomechanical model of the heart and Fontan circulation with the components of systemic and pulmonary beds to augment the diagnostic assessment of the patients undergoing the XMR stress exam. We apply our model in 3 Fontan patients and one biventricular ``control" case. In all subjects, we obtained important biophysical factors of cardiovascular physiology -- contractility, contractile reserve and changes in systemic and pulmonary vascular resistance -- which contribute to explaining the mechanism of failure in individual patients. Finally, we used the patient-specific model of one Fontan patient to investigate the impact of changes in pulmonary vascular resistance, aiming at in silico testing of pulmonary vasodilation treatments.

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