TY - JOUR
T1 - Modelling the Interaction of Magnetic Particles in Blood Vessels and a Bulk Superconducting Magnet
AU - Xu, Zhenyang
AU - Ainslie, Mark
N1 - Publisher Copyright:
© 2002-2011 IEEE.
PY - 2024/11/21
Y1 - 2024/11/21
N2 - Magnetic drug targeting (MDT) is one of the most effective drug delivery systems for multi-disease therapy. Since a bulk superconducting magnet could generate a superior magnetic field strength and gradient, there is great potential for achieving MDT external to the body. In this work, a three-dimensional Y-shaped blood vessel and bulk superconducting magnet model are built in the finite-element software package COMSOL Multiphysics. The model is used to simulate the drug delivery process via the bulk superconducting magnet. The results show that the bulk superconducting magnet can be used to improve the capture efficiency (CE) of magnetic particles (drug carriers) under a large range of conditions, including magnet position, particle diameter, magnet-tube distance, operating temperature for the magnet, and magnet size. It should be noted that, for a bulk magnet of dimensions a = 10 mm, t = 10 mm, at a distance d = 12 mm, with an operating temperature T = 50 K, and magnetic particle size dp = 10 μm, the CE could be almost as high as 80%. In summary, this modelling framework provides a basis for guiding the design of a practical, external superconducting MDT system in the near future.
AB - Magnetic drug targeting (MDT) is one of the most effective drug delivery systems for multi-disease therapy. Since a bulk superconducting magnet could generate a superior magnetic field strength and gradient, there is great potential for achieving MDT external to the body. In this work, a three-dimensional Y-shaped blood vessel and bulk superconducting magnet model are built in the finite-element software package COMSOL Multiphysics. The model is used to simulate the drug delivery process via the bulk superconducting magnet. The results show that the bulk superconducting magnet can be used to improve the capture efficiency (CE) of magnetic particles (drug carriers) under a large range of conditions, including magnet position, particle diameter, magnet-tube distance, operating temperature for the magnet, and magnet size. It should be noted that, for a bulk magnet of dimensions a = 10 mm, t = 10 mm, at a distance d = 12 mm, with an operating temperature T = 50 K, and magnetic particle size dp = 10 μm, the CE could be almost as high as 80%. In summary, this modelling framework provides a basis for guiding the design of a practical, external superconducting MDT system in the near future.
KW - applied superconductivity
KW - bulk superconducting magnet
KW - trapped field magnets
KW - magnetic drug targeting
KW - numerical simulation
KW - finite element method
UR - http://www.scopus.com/inward/record.url?scp=85210129902&partnerID=8YFLogxK
U2 - 10.1109/TASC.2024.3504473
DO - 10.1109/TASC.2024.3504473
M3 - Article
SN - 1051-8223
VL - 35
JO - IEEE Transactions on Applied Superconductivity
JF - IEEE Transactions on Applied Superconductivity
IS - 5
M1 - 3700106
ER -
