Modelling from the experimental developmental biologists viewpoint

Andrew Economou; Jeremy Green

doi:10.1016/j.semcdb.2014.07.006

Modelling from the experimental developmental biologists viewpoint

Andrew Economou, Jeremy Green

Centre for Craniofacial & Regenerative Biology

Research output: Contribution to journal › Literature review › peer-review

19 Citations (Scopus)

Abstract

In this review we consider Reaction Diffusion as the archetype of a model in developmental biology. We consider its history in relation to experimental work since it was first proposed in 1952 by Turing and revived in the 19705 by Meinhardt. We then discuss the most recent examples of experiments that address this model, including the challenges that remain in capturing the physico-chemical manifestation of the model mechanism in a real developmental system. Finally we discuss the model's current status and use in the experimental community. (C) 2014 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	58-65
Number of pages	8
Journal	Seminars in Cell and Developmental Biology
Volume	35
DOIs	https://doi.org/10.1016/j.semcdb.2014.07.006
Publication status	Published - Nov 2014

Keywords

Chemical morphogenesis
Turing systems
Reaction-Diffusion
Morphogens
LALI
REACTION-DIFFUSION MECHANISMS
PATTERN-FORMATION
LATERAL-INHIBITION
HETEROCYST DIFFERENTIATION
FEATHER MORPHOGENESIS
SELF-ENHANCEMENT
VERTEBRATE LIMB
TURING PATTERNS
HAIR
GENERATION

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10.1016/j.semcdb.2014.07.006

19 Citations
1 Article

Perturbation analysis of a multi-morphogen Turing Reaction-Diffusion stripe patterning system reveals key regulatory interactions
Economou, A., Monk, N. A. M. & Green, J., 29 Oct 2020, In: Development (Cambridge). 147, 20, 13 p., dev190553.
Research output: Contribution to journal › Article › peer-review

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15 Citations (Scopus)

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title = "Modelling from the experimental developmental biologists viewpoint",

abstract = "In this review we consider Reaction Diffusion as the archetype of a model in developmental biology. We consider its history in relation to experimental work since it was first proposed in 1952 by Turing and revived in the 19705 by Meinhardt. We then discuss the most recent examples of experiments that address this model, including the challenges that remain in capturing the physico-chemical manifestation of the model mechanism in a real developmental system. Finally we discuss the model's current status and use in the experimental community. (C) 2014 Elsevier Ltd. All rights reserved.",

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author = "Andrew Economou and Jeremy Green",

year = "2014",

month = nov,

doi = "10.1016/j.semcdb.2014.07.006",

language = "English",

volume = "35",

pages = "58--65",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Modelling from the experimental developmental biologists viewpoint

AU - Economou, Andrew

AU - Green, Jeremy

PY - 2014/11

Y1 - 2014/11

N2 - In this review we consider Reaction Diffusion as the archetype of a model in developmental biology. We consider its history in relation to experimental work since it was first proposed in 1952 by Turing and revived in the 19705 by Meinhardt. We then discuss the most recent examples of experiments that address this model, including the challenges that remain in capturing the physico-chemical manifestation of the model mechanism in a real developmental system. Finally we discuss the model's current status and use in the experimental community. (C) 2014 Elsevier Ltd. All rights reserved.

AB - In this review we consider Reaction Diffusion as the archetype of a model in developmental biology. We consider its history in relation to experimental work since it was first proposed in 1952 by Turing and revived in the 19705 by Meinhardt. We then discuss the most recent examples of experiments that address this model, including the challenges that remain in capturing the physico-chemical manifestation of the model mechanism in a real developmental system. Finally we discuss the model's current status and use in the experimental community. (C) 2014 Elsevier Ltd. All rights reserved.

KW - Chemical morphogenesis

KW - Turing systems

KW - Reaction-Diffusion

KW - Morphogens

KW - LALI

KW - REACTION-DIFFUSION MECHANISMS

KW - PATTERN-FORMATION

KW - LATERAL-INHIBITION

KW - HETEROCYST DIFFERENTIATION

KW - FEATHER MORPHOGENESIS

KW - SELF-ENHANCEMENT

KW - VERTEBRATE LIMB

KW - TURING PATTERNS

KW - HAIR

KW - GENERATION

U2 - 10.1016/j.semcdb.2014.07.006

DO - 10.1016/j.semcdb.2014.07.006

M3 - Literature review

SN - 1084-9521

VL - 35

SP - 58

EP - 65

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -

Modelling from the experimental developmental biologists viewpoint

Abstract

Keywords

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Research output

Perturbation analysis of a multi-morphogen Turing Reaction-Diffusion stripe patterning system reveals key regulatory interactions

Cite this