Modelling pulse wave propagation in the rabbit systemic circulation to assess the effects of altered nitric oxide synthesis

TY - JOUR

T1 - Modelling pulse wave propagation in the rabbit systemic circulation to assess the effects of altered nitric oxide synthesis

AU - Alastruey, Jordi

AU - Nagel, Simon R.

AU - Nier, Bettina A.

AU - Hunt, Anthony A. E.

AU - Weinberg, Peter D.

AU - Peiro, Joaquim

PY - 2009/9/18

Y1 - 2009/9/18

N2 - Pulse wave propagation in the mature rabbit systemic circulation was simulated using the one-dimensional equations of blood flow in compliant vessels. A corrosion cast of the rabbit circulation was manufactured to obtain arterial lengths and diameters. Pulse wave speeds and inflow and outflow boundary conditions were derived from in vivo data. Numerical results captured the main features of in vivo pressure and velocity pulse waveforms in the aorta, brachiocephalic artery and central ear artery. This model was used to elucidate haemodynamic mechanisms underlying changes in peripheral pulse waveforms observed in vivo after administering drugs that alter nitric oxide synthesis in the endothelial cells lining blood vessels. According to our model, these changes can be explained by single or combined alterations of blood viscosity, peripheral resistance and compliance, and the elasticity of conduit arteries.

AB - Pulse wave propagation in the mature rabbit systemic circulation was simulated using the one-dimensional equations of blood flow in compliant vessels. A corrosion cast of the rabbit circulation was manufactured to obtain arterial lengths and diameters. Pulse wave speeds and inflow and outflow boundary conditions were derived from in vivo data. Numerical results captured the main features of in vivo pressure and velocity pulse waveforms in the aorta, brachiocephalic artery and central ear artery. This model was used to elucidate haemodynamic mechanisms underlying changes in peripheral pulse waveforms observed in vivo after administering drugs that alter nitric oxide synthesis in the endothelial cells lining blood vessels. According to our model, these changes can be explained by single or combined alterations of blood viscosity, peripheral resistance and compliance, and the elasticity of conduit arteries.

KW - Pulse wave propagation

KW - Rabbit systemic circulation

KW - One-dimensional modelling

KW - Dicrotic notch

KW - Nitric oxide

KW - Corrosion cast

U2 - 10.1016/j.jbiomech.2009.05.028

DO - 10.1016/j.jbiomech.2009.05.028

M3 - Article

SN - 0021-9290

VL - 42

SP - 2116

EP - 2123

JO - Journal of Biomechanics

JF - Journal of Biomechanics

IS - 13

M1 - N/A

ER -