TY - CHAP
T1 - Modelling the Effects of Conductive Polymers and Stem Cells Derived Myocytes on Scarred Heart Tissue
AU - Fassina, Damiano
AU - Costa, Caroline Mendonca
AU - Longobardi, Stefano
AU - Harding, Sian E.
AU - Niederer, Steven A.
N1 - Funding Information:
This research project is funded by a British Heart Foundation, Centre of Regenerative Medicine – NHLI Studentship.
Publisher Copyright:
© 2020 Creative Commons; the authors hold their copyright.
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2020/9/13
Y1 - 2020/9/13
N2 - Myocardial infarction leads to permanent tissue scars that impairs cardiac function and can result in heart failure. The use of engineered heart tissue (EHT) and conductive polymers (CP) in regenerative medicine aims to assist tissue recovery and improve of cardiac function. However, the attachment of EHT to the epicardium may disrupt tissue electrophysiology and lead to an increased arrhythmia risk. We investigated the role that material properties, i.e. EHT and CP conductivity and thickness and EHT-tissue contact area, play in cardiac recovery, in the presence of scars with different depth, length and conductivity. We created a 2D model to simulate EHT and CP placed over a scar in rabbit ventricle. We performed a Global Sensitivity Analysis (GSA) to identify which parameters had the largest impact on electrical propagation across the scar and the EHT. Our model showed that in case of non-transmural scar the main determinants were scar depth and conductivity, explaining 30% and 33% of the variance, respectively. However, in case of transmural scar, the model indicated the EHT conductivity and the extent of the EHT-tissue contact explain 40% and 46% of the variance, respectively.
AB - Myocardial infarction leads to permanent tissue scars that impairs cardiac function and can result in heart failure. The use of engineered heart tissue (EHT) and conductive polymers (CP) in regenerative medicine aims to assist tissue recovery and improve of cardiac function. However, the attachment of EHT to the epicardium may disrupt tissue electrophysiology and lead to an increased arrhythmia risk. We investigated the role that material properties, i.e. EHT and CP conductivity and thickness and EHT-tissue contact area, play in cardiac recovery, in the presence of scars with different depth, length and conductivity. We created a 2D model to simulate EHT and CP placed over a scar in rabbit ventricle. We performed a Global Sensitivity Analysis (GSA) to identify which parameters had the largest impact on electrical propagation across the scar and the EHT. Our model showed that in case of non-transmural scar the main determinants were scar depth and conductivity, explaining 30% and 33% of the variance, respectively. However, in case of transmural scar, the model indicated the EHT conductivity and the extent of the EHT-tissue contact explain 40% and 46% of the variance, respectively.
UR - http://www.scopus.com/inward/record.url?scp=85100942498&partnerID=8YFLogxK
U2 - 10.22489/CinC.2020.223
DO - 10.22489/CinC.2020.223
M3 - Conference paper
AN - SCOPUS:85100942498
T3 - Computing in Cardiology
BT - 2020 Computing in Cardiology, CinC 2020
PB - IEEE Computer Society
T2 - 2020 Computing in Cardiology, CinC 2020
Y2 - 13 September 2020 through 16 September 2020
ER -