Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

TY - JOUR

T1 - Moderate Champagne consumption promotes an acute improvement in acute endothelial-independent vascular function in healthy human volunteers

AU - Vauzour, David

AU - Houseman, Emily J

AU - George, Trevor W

AU - Corona, Giulia

AU - Garnotel, Roselyne

AU - Jackson, Kim G

AU - Sellier, Christelle

AU - Gillery, Philippe

AU - Kennedy, Orla B

AU - Lovegrove, Julie A

AU - Spencer, Jeremy P E

PY - 2010/4

Y1 - 2010/4

N2 - Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.

AB - Epidemiological studies have suggested an inverse correlation between red wine consumption and the incidence of CVD. However, Champagne wine has not been fully investigated for its cardioprotective potential. In order to assess whether acute and moderate Champagne wine consumption is capable of modulating vascular function, we performed a randomised, placebo-controlled, cross-over intervention trial. We show that consumption of Champagne wine, but not a control matched for alcohol, carbohydrate and fruit-derived acid content, induced an acute change in endothelium-independent vasodilatation at 4 and 8 h post-consumption. Although both Champagne wine and the control also induced an increase in endothelium-dependent vascular reactivity at 4 h, there was no significant difference between the vascular effects induced by Champagne or the control at any time point. These effects were accompanied by an acute decrease in the concentration of matrix metalloproteinase (MMP-9), a significant decrease in plasma levels of oxidising species and an increase in urinary excretion of a number of phenolic metabolites. In particular, the mean total excretion of hippuric acid, protocatechuic acid and isoferulic acid were all significantly greater following the Champagne wine intervention compared with the control intervention. Our data suggest that a daily moderate consumption of Champagne wine may improve vascular performance via the delivery of phenolic constituents capable of improving NO bioavailability and reducing matrix metalloproteinase activity.

KW - Adult

KW - Aged

KW - Alcohol Drinking

KW - Cross-Over Studies

KW - Endothelium, Vascular

KW - Female

KW - Flavonoids

KW - Humans

KW - Iontophoresis

KW - Laser-Doppler Flowmetry

KW - Male

KW - Matrix Metalloproteinase 9

KW - Middle Aged

KW - Oxidants

KW - Phenols

KW - Polyphenols

KW - Single-Blind Method

KW - Tissue Inhibitor of Metalloproteinases

KW - Vasodilation

KW - Wine

KW - Young Adult

U2 - 10.1017/S0007114509992959

DO - 10.1017/S0007114509992959

M3 - Article

C2 - 19943984

SN - 0007-1145

VL - 103

SP - 1168

EP - 1178

JO - British Journal of Nutrition

JF - British Journal of Nutrition

IS - 8

ER -