Modes of invasion during tumour dissemination

Research output: Contribution to journalReview articlepeer-review

123 Citations (Scopus)

Abstract

Cancer cell migration and invasion underlie metastatic dissemination, one of the major problems in cancer. Tumour cells exhibit a striking variety of invasion strategies. Importantly, cancer cells can switch between invasion modes in order to cope with challenging environments. This ability to switch migratory modes or plasticity highlights the challenges behind antimetastasis therapy design. In this Review, we present current knowledge on different tumour invasion strategies, the determinants controlling plasticity and arising therapeutic opportunities. We propose that targeting master regulators controlling plasticity is needed to hinder tumour dissemination and metastasis.

Original languageEnglish
Pages (from-to)5-27
Number of pages23
JournalMolecular Oncology
Volume11
Issue number1
Early online date3 Nov 2016
DOIs
Publication statusPublished - Jan 2017

Keywords

  • actomyosin contractility
  • cancer metastasis
  • invasion
  • plasticity
  • Rho GTPases

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