King's College London

Research portal

Modulation of Adult Hippocampal Neurogenesis by Sleep: Impact on Mental Health

Research output: Contribution to journalArticle

Cristina Navarro-Sanchis, Olivier Brock, Raphaelle Winsky-Sommerer, Sandrine Thuret

Original languageEnglish
JournalFrontiers in Neural Circuits
Volume11
Early online date12 Oct 2017
DOIs
Accepted/In press26 Sep 2017
E-pub ahead of print12 Oct 2017
PublishedOct 2017

Documents

King's Authors

Abstract

The process of neurogenesis has been demonstrated to occur throughout life in the subgranular zone (SGZ) of the hippocampal dentate gyrus of several mammals, including humans. The basal rate of adult hippocampal neurogenesis can be altered by lifestyle and environmental factors. In this perspective review, the evidence for sleep as a modulator of adult hippocampal neurogenesis is first summarized. Following this, the impacts of sleep and sleep disturbances on hippocampal-dependent functions, including learning and memory, and depression are critically evaluated. Finally, we postulate that the effects of sleep on hippocampal-dependent functions may possibly be mediated by a change in adult hippocampal neurogenesis. This could provide a route to new treatments for cognitive impairments and psychiatric disorders.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454