Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol

Paolo Fusar-Poli; Paul Allen; Sagnik Bhattacharyya; Jose A. Crippa; Andrea Mechelli; Stefan Borgwardt; Rocio Martin-Santos; Marc L. Seal; Colin O'Carrol; Zerrin Atakan; Antonio W. Zuardi; Philip McGuire

doi:10.1017/S1461145709990617

Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol

Paolo Fusar-Poli, Paul Allen, Sagnik Bhattacharyya, Jose A. Crippa, Andrea Mechelli, Stefan Borgwardt, Rocio Martin-Santos, Marc L. Seal, Colin O'Carrol, Zerrin Atakan, Antonio W. Zuardi, Philip McGuire

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129 Citations (Scopus)

Abstract

Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta(9)-tetrahydrocannabinol (Delta(9)-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta(9)-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocrtical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.

Original language	English
Pages (from-to)	421-432
Number of pages	12
Journal	International Journal of Neuropsychopharmacology
Volume	13
Issue number	4
DOIs	https://doi.org/10.1017/S1461145709990617
Publication status	Published - May 2010

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Fusar-Poli, P., Allen, P., Bhattacharyya, S., Crippa, J. A., Mechelli, A., Borgwardt, S., Martin-Santos, R., Seal, M. L., O'Carrol, C., Atakan, Z., Zuardi, A. W., & McGuire, P. (2010). Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol. International Journal of Neuropsychopharmacology , 13(4), 421-432. https://doi.org/10.1017/S1461145709990617

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title = "Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol",

abstract = "Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta(9)-tetrahydrocannabinol (Delta(9)-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta(9)-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocrtical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.",

author = "Paolo Fusar-Poli and Paul Allen and Sagnik Bhattacharyya and Crippa, {Jose A.} and Andrea Mechelli and Stefan Borgwardt and Rocio Martin-Santos and Seal, {Marc L.} and Colin O'Carrol and Zerrin Atakan and Zuardi, {Antonio W.} and Philip McGuire",

year = "2010",

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Fusar-Poli, P, Allen, P, Bhattacharyya, S, Crippa, JA, Mechelli, A , Borgwardt, S, Martin-Santos, R, Seal, ML, O'Carrol, C, Atakan, Z, Zuardi, AW & McGuire, P 2010, 'Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol', International Journal of Neuropsychopharmacology , vol. 13, no. 4, pp. 421-432. https://doi.org/10.1017/S1461145709990617

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AU - Fusar-Poli, Paolo

AU - Allen, Paul

AU - Bhattacharyya, Sagnik

AU - Crippa, Jose A.

AU - Mechelli, Andrea

AU - Borgwardt, Stefan

AU - Martin-Santos, Rocio

AU - Seal, Marc L.

AU - O'Carrol, Colin

AU - Atakan, Zerrin

AU - Zuardi, Antonio W.

AU - McGuire, Philip

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AB - Cannabis sativa, the most widely used illicit drug, has profound effects on levels of anxiety in animals and humans. Although recent studies have helped provide a better understanding of the neurofunctional correlates of these effects, indicating the involvement of the amygdala and cingulate cortex, their reciprocal influence is still mostly unknown. In this study dynamic causal modelling (DCM) and Bayesian model selection (BMS) were used to explore the effects of pure compounds of C. sativa [600 mg of cannabidiol (CBD) and 10 mg Delta(9)-tetrahydrocannabinol (Delta(9)-THC)] on prefrontal-subcortical effective connectivity in 15 healthy subjects who underwent a double-blind randomized, placebo-controlled fMRI paradigm while viewing faces which elicited different levels of anxiety. In the placebo condition, BMS identified a model with driving inputs entering via the anterior cingulate and forward intrinsic connectivity between the amygdala and the anterior cingulate as the best fit. CBD but not Delta(9)-THC disrupted forward connectivity between these regions during the neural response to fearful faces. This is the first study to show that the disruption of prefrontal-subocrtical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties.

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DO - 10.1017/S1461145709990617

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JO - International Journal of Neuropsychopharmacology

JF - International Journal of Neuropsychopharmacology

IS - 4

ER -

Modulation of effective connectivity during emotional processing by Δ9-tetrahydrocannabinol and cannabidiol

Abstract

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