TY - JOUR
T1 - Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering
T2 - A Literature Review
AU - Florimond, Marion
AU - Minic, Sandra
AU - Sharpe, Paul
AU - Chaussain, Catherine
AU - Renard, Emmanuelle
AU - Boukpessi, Tchilalo
N1 - Funding Information:
Minic, S is a student of the University of Paris whose thesis was co-funded by the French Ministry of Higher Education and Research (CIFRE fellowship No 2018/1781) and Septodont. The other authors have no potential conflicts of interest to declare in relation to the authorship and/or publication of this article.
Publisher Copyright:
© 2022 by the authors.
PY - 2022/9/13
Y1 - 2022/9/13
N2 - The main goal of vital pulp therapy (VPT) is to preserve the vitality of the pulp tissue, even when it is exposed due to bacterial invasion, iatrogenic mechanical preparation, or trauma. The type of new dentin formed as a result of VPT can differ in its cellular origin, its microstructure, and its barrier function. It is generally agreed that the new dentin produced by odontoblasts (reactionary dentin) has a tubular structure, while the dentin produced by pulp cells (reparative dentin) does not or has less. Thus, even VPT aims to maintain the vitality of the pulp. It does not regenerate the dentin pulp complex integrity. Therefore, many studies have sought to identify new therapeutic strategies to successfully regenerate the dentin pulp complex. Among them is a Wnt protein-based strategy based on the fact that Wnt proteins seem to be powerful stem cell factors that allow control of the self-renewal and proliferation of multiple adult stem cell populations, suitable for homeostasis maintenance, tissue healing, and regeneration promotion. Thus, this review outlines the different agents targeting the Wnt signaling that could be applied in a tooth environment, and could be a potential therapy for dentin pulp complex and bone regeneration.
AB - The main goal of vital pulp therapy (VPT) is to preserve the vitality of the pulp tissue, even when it is exposed due to bacterial invasion, iatrogenic mechanical preparation, or trauma. The type of new dentin formed as a result of VPT can differ in its cellular origin, its microstructure, and its barrier function. It is generally agreed that the new dentin produced by odontoblasts (reactionary dentin) has a tubular structure, while the dentin produced by pulp cells (reparative dentin) does not or has less. Thus, even VPT aims to maintain the vitality of the pulp. It does not regenerate the dentin pulp complex integrity. Therefore, many studies have sought to identify new therapeutic strategies to successfully regenerate the dentin pulp complex. Among them is a Wnt protein-based strategy based on the fact that Wnt proteins seem to be powerful stem cell factors that allow control of the self-renewal and proliferation of multiple adult stem cell populations, suitable for homeostasis maintenance, tissue healing, and regeneration promotion. Thus, this review outlines the different agents targeting the Wnt signaling that could be applied in a tooth environment, and could be a potential therapy for dentin pulp complex and bone regeneration.
KW - dentin pulp complex regeneration engineering
KW - small molecules
KW - Wnt signal
UR - http://www.scopus.com/inward/record.url?scp=85138409700&partnerID=8YFLogxK
U2 - 10.3390/ijms231810582
DO - 10.3390/ijms231810582
M3 - Review article
C2 - 36142496
AN - SCOPUS:85138409700
SN - 1661-6596
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 18
M1 - 10582
ER -