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Modulators of Wnt Signaling Pathway Implied in Dentin Pulp Complex Engineering: A Literature Review

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Marion Florimond, Sandra Minic, Paul Sharpe, Catherine Chaussain, Emmanuelle Renard, Tchilalo Boukpessi

Original languageEnglish
Article number10582
JournalInternational Journal of Molecular Sciences
Issue number18
Published13 Sep 2022

Bibliographical note

Funding Information: Minic, S is a student of the University of Paris whose thesis was co-funded by the French Ministry of Higher Education and Research (CIFRE fellowship No 2018/1781) and Septodont. The other authors have no potential conflicts of interest to declare in relation to the authorship and/or publication of this article. Publisher Copyright: © 2022 by the authors.

King's Authors


The main goal of vital pulp therapy (VPT) is to preserve the vitality of the pulp tissue, even when it is exposed due to bacterial invasion, iatrogenic mechanical preparation, or trauma. The type of new dentin formed as a result of VPT can differ in its cellular origin, its microstructure, and its barrier function. It is generally agreed that the new dentin produced by odontoblasts (reactionary dentin) has a tubular structure, while the dentin produced by pulp cells (reparative dentin) does not or has less. Thus, even VPT aims to maintain the vitality of the pulp. It does not regenerate the dentin pulp complex integrity. Therefore, many studies have sought to identify new therapeutic strategies to successfully regenerate the dentin pulp complex. Among them is a Wnt protein-based strategy based on the fact that Wnt proteins seem to be powerful stem cell factors that allow control of the self-renewal and proliferation of multiple adult stem cell populations, suitable for homeostasis maintenance, tissue healing, and regeneration promotion. Thus, this review outlines the different agents targeting the Wnt signaling that could be applied in a tooth environment, and could be a potential therapy for dentin pulp complex and bone regeneration.

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