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Molecular diversity underlying cortical excitatory and inhibitory synapse development: Developmental Neuroscience

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)8-15
Number of pages8
JournalCURRENT OPINION IN NEUROBIOLOGY
Volume53
Early online date25 Apr 2018
DOIs
Publication statusPublished - Dec 2018

King's Authors

Abstract

The complexity and precision of cortical circuitries is achieved during development due to the exquisite diversity of synapse types that is generated in a highly regulated manner. Here, we review the recent increase in our understanding of how synapse type-specific molecules differentially regulate the development of excitatory and inhibitory synapses. Moreover, several synapse subtype-specific molecules have been shown to control the targeting, formation or maturation of particular subtypes of excitatory synapses. Because inhibitory neurons are extremely diverse, a similar molecular diversity is likely to underlie the development of different inhibitory synapses making it a promising topic for future investigation in the field of the synapse development.

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