Molecular genetic gene-environment studies using candidate genes in schizophrenia: A systematic review

TY - JOUR

T1 - Molecular genetic gene-environment studies using candidate genes in schizophrenia

T2 - A systematic review

AU - Modinos, Gemma

AU - Iyegbe, Conrad

AU - Prata, Diana

AU - Rivera, Margarita

AU - Kempton, Matthew J

AU - Valmaggia, Lucia R

AU - Sham, Pak C

AU - Van Os, Jim

AU - McGuire, Philip

PY - 2013/11

Y1 - 2013/11

N2 - The relatively high heritability of schizophrenia suggests that genetic factors play an important role in the etiology of the disorder. On the other hand, a number of environmental factors significantly influence its incidence. As few direct genetic effects have been demonstrated, and there is considerable inter-individual heterogeneity in the response to the known environmental factors, interactions between genetic and environmental factors may be important in determining whether an individual develops the disorder. To date, a considerable number of studies of gene-environment interactions (G×E) in schizophrenia have employed a hypothesis-based molecular genetic approach using candidate genes, which have led to a range of different findings. This systematic review aims to summarize the results from molecular genetic candidate studies and to review challenges and opportunities of this approach in psychosis research. Finally, we discuss the potential of future prospects, such as new studies that combine hypothesis-based molecular genetic candidate approaches with agnostic genome-wide association studies in determining schizophrenia risk.

AB - The relatively high heritability of schizophrenia suggests that genetic factors play an important role in the etiology of the disorder. On the other hand, a number of environmental factors significantly influence its incidence. As few direct genetic effects have been demonstrated, and there is considerable inter-individual heterogeneity in the response to the known environmental factors, interactions between genetic and environmental factors may be important in determining whether an individual develops the disorder. To date, a considerable number of studies of gene-environment interactions (G×E) in schizophrenia have employed a hypothesis-based molecular genetic approach using candidate genes, which have led to a range of different findings. This systematic review aims to summarize the results from molecular genetic candidate studies and to review challenges and opportunities of this approach in psychosis research. Finally, we discuss the potential of future prospects, such as new studies that combine hypothesis-based molecular genetic candidate approaches with agnostic genome-wide association studies in determining schizophrenia risk.

U2 - 10.1016/j.schres.2013.09.010

DO - 10.1016/j.schres.2013.09.010

M3 - Article

C2 - 24094883

SN - 0920-9964

VL - 150

SP - 356

EP - 365

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -