Molecular mechanisms involved in intestinal iron absorption

TY - JOUR

T1 - Molecular mechanisms involved in intestinal iron absorption

AU - Sharp, P

AU - Srai, S K

PY - 2007/9/21

Y1 - 2007/9/21

N2 - Iron is an essential trace metal in the human diet due to its obligate role in a number of metabolic processes. In the diet, iron is present in a number of different forms, generally described as haem (from haemoglobin and myoglobin in animal tissue) and non-haem iron (including ferric oxides and salts, ferritin and lactoferrin). This review describes the molecular mechanisms that co-ordinate the absorption of iron from the diet and its release into the circulation. While many components of the iron transport pathway have been elucidated, a number of key issues still remain to be resolved. Future work in this area will provide a clearer picture regarding the transcellular flux of iron and its regulation by dietary and humoral factors. (C) 2007 WJG. All rights reserved

AB - Iron is an essential trace metal in the human diet due to its obligate role in a number of metabolic processes. In the diet, iron is present in a number of different forms, generally described as haem (from haemoglobin and myoglobin in animal tissue) and non-haem iron (including ferric oxides and salts, ferritin and lactoferrin). This review describes the molecular mechanisms that co-ordinate the absorption of iron from the diet and its release into the circulation. While many components of the iron transport pathway have been elucidated, a number of key issues still remain to be resolved. Future work in this area will provide a clearer picture regarding the transcellular flux of iron and its regulation by dietary and humoral factors. (C) 2007 WJG. All rights reserved

M3 - Literature review

VL - 13

SP - 4716

EP - 4724

JO - World Journal of Gastroenterology

JF - World Journal of Gastroenterology

IS - 35

ER -