Molecular Mechanisms Leading from Periodontal Disease to Cancer

Bartosz Kamil Sobocki; Charbel A. Basset; Bożena Bruhn-Olszewska; Paweł Olszewski; Olga Szot; Karolina Kaźmierczak-Siedlecka; Mateusz Guziak; Luigi Nibali; Angelo Leone

doi:10.3390/ijms23020970

Molecular Mechanisms Leading from Periodontal Disease to Cancer

Bartosz Kamil Sobocki^*, Charbel A. Basset, Bożena Bruhn-Olszewska, Paweł Olszewski, Olga Szot, Karolina Kaźmierczak-Siedlecka, Mateusz Guziak, Luigi Nibali, Angelo Leone

^*Corresponding author for this work

Centre for Host Microbiome Interactions

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

Abstract

Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.

Original language	English
Article number	970
Journal	International Journal of Molecular Sciences
Volume	23
Issue number	2
DOIs	https://doi.org/10.3390/ijms23020970
Publication status	Published - 1 Jan 2022

Keywords

Cancer
Fusobacterium nucleatum
Immune response
Periodontal disease
Porphyromonas gingivalis
RANK ligand
Tumorigenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.3390/ijms23020970

Cite this

@article{6e0809514b244eaeaebc2fb32eaef959,

title = "Molecular Mechanisms Leading from Periodontal Disease to Cancer",

abstract = "Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.",

keywords = "Cancer, Fusobacterium nucleatum, Immune response, Periodontal disease, Porphyromonas gingivalis, RANK ligand, Tumorigenesis",

author = "Sobocki, {Bartosz Kamil} and Basset, {Charbel A.} and Bo{\.z}ena Bruhn-Olszewska and Pawe{\l} Olszewski and Olga Szot and Karolina Ka{\'z}mierczak-Siedlecka and Mateusz Guziak and Luigi Nibali and Angelo Leone",

note = "Funding Information: This research received no external funding. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2022",

month = jan,

day = "1",

doi = "10.3390/ijms23020970",

language = "English",

volume = "23",

journal = "International Journal of Molecular Sciences",

issn = "1661-6596",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "2",

}

TY - JOUR

T1 - Molecular Mechanisms Leading from Periodontal Disease to Cancer

AU - Sobocki, Bartosz Kamil

AU - Basset, Charbel A.

AU - Bruhn-Olszewska, Bożena

AU - Olszewski, Paweł

AU - Szot, Olga

AU - Kaźmierczak-Siedlecka, Karolina

AU - Guziak, Mateusz

AU - Nibali, Luigi

AU - Leone, Angelo

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.

AB - Periodontitis is prevalent in half of the adult population and raises critical health concerns as it has been recently associated with an increased risk of cancer. While information about the topic remains somewhat scarce, a deeper understanding of the underlying mechanistic pathways promoting neoplasia in periodontitis patients is of fundamental importance. This manuscript presents the literature as well as a panel of tables and figures on the molecular mechanisms of Porphyromonas gingivalis and Fusobacterium nucleatum, two main oral pathogens in periodontitis pathology, involved in instigating tumorigenesis. We also present evidence for potential links between the RANKL–RANK signaling axis as well as circulating cytokines/leukocytes and carcinogenesis. Due to the nonconclusive data associating periodontitis and cancer reported in the case and cohort studies, we examine clinical trials relevant to the topic and summarize their outcome.

KW - Cancer

KW - Fusobacterium nucleatum

KW - Immune response

KW - Periodontal disease

KW - Porphyromonas gingivalis

KW - RANK ligand

KW - Tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=85122826797&partnerID=8YFLogxK

U2 - 10.3390/ijms23020970

DO - 10.3390/ijms23020970

M3 - Article

AN - SCOPUS:85122826797

SN - 1661-6596

VL - 23

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 2

M1 - 970

ER -

Molecular Mechanisms Leading from Periodontal Disease to Cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this