Molecular regulation of ocular gland development

TY - JOUR

T1 - Molecular regulation of ocular gland development

AU - Miletich, Isabelle

PY - 2018/9/25

Y1 - 2018/9/25

N2 - The tear film is produced by two ocular glands, the lacrimal glands, which produce the aqueous component of this film, and the meibomian glands, which secrete the lipidic component that is key to reduce evaporation of the watery film at the surface of the eye. Embryonic development of these exocrine glands has been mostly studied in mice, which also develop Harderian glands, a third type of ocular gland whose role is still not well understood. This review provides an update on the signalling pathways, transcription factors andextracellular matrix components that have been shown to play a role in ocular gland development.

AB - The tear film is produced by two ocular glands, the lacrimal glands, which produce the aqueous component of this film, and the meibomian glands, which secrete the lipidic component that is key to reduce evaporation of the watery film at the surface of the eye. Embryonic development of these exocrine glands has been mostly studied in mice, which also develop Harderian glands, a third type of ocular gland whose role is still not well understood. This review provides an update on the signalling pathways, transcription factors andextracellular matrix components that have been shown to play a role in ocular gland development.

U2 - 10.1016/j.semcdb.2018.07.023

DO - 10.1016/j.semcdb.2018.07.023

M3 - Review article

SN - 1084-9521

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

ER -