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Molecular regulation of ocular gland development

Research output: Contribution to journalReview article

Original languageEnglish
JournalSeminars in Cell and Developmental Biology
Early online date25 Sep 2018
DOIs
Publication statusE-pub ahead of print - 25 Sep 2018

King's Authors

Abstract

The tear film is produced by two ocular glands, the lacrimal glands, which produce the aqueous component of this film, and the meibomian glands, which secrete the lipidic component that is key to reduce evaporation of the watery film at the surface of the eye. Embryonic development of these exocrine glands has been mostly studied in mice, which also develop Harderian glands, a third type of ocular gland whose role is still not well understood. This review provides an update on the signalling pathways, transcription factors andextracellular matrix components that have been shown to play a role in ocular gland development.

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