TY - JOUR
T1 - Monitoring the response to neoadjuvant hormone therapy for locally advanced breast cancer using three-dimensional time-resolved optical mammography
AU - Enfield, Louise
AU - Cantanhede, Gabriel
AU - Douek, Michael
AU - Ramalingam, Vernie
AU - Purushotham, Arnie
AU - Hebden, Jem
AU - Gibson, Adam
PY - 2013/5
Y1 - 2013/5
N2 - Optical mammography is a functional imaging technique that uses near-infrared light to produce threedimensional breast images of tissue oxygen saturation and hemoglobin concentration. It has been used to monitor the response to neoadjuvant chemotherapy in breast cancer patients. We present the first results on monitoring tumor response to hormone therapy using optical mammography. We present three case studies from postmenopausal women treated with neoadjuvant hormone therapy for locally advanced breast cancer. The women were scanned before starting treatment, once during treatment, and then before surgery. Changes in physiological and optical properties within the tumor and in the rest of the breast were evaluated. At the time of surgery, two patients partially responded to treatment and one did not respond. The patients that partially responded on ultrasound revealed a corresponding recovery to normal in the hemoglobin concentration images, whereas the nonresponder indicated an increase in hemoglobin concentration in the tumor compared to her pretreatment images. These case studies suggest that optical imaging of the breast during neoadjuvant hormone treatment can provide potentially valuable information, and that physiological changes within the tumor can be seen in response to treatment.
AB - Optical mammography is a functional imaging technique that uses near-infrared light to produce threedimensional breast images of tissue oxygen saturation and hemoglobin concentration. It has been used to monitor the response to neoadjuvant chemotherapy in breast cancer patients. We present the first results on monitoring tumor response to hormone therapy using optical mammography. We present three case studies from postmenopausal women treated with neoadjuvant hormone therapy for locally advanced breast cancer. The women were scanned before starting treatment, once during treatment, and then before surgery. Changes in physiological and optical properties within the tumor and in the rest of the breast were evaluated. At the time of surgery, two patients partially responded to treatment and one did not respond. The patients that partially responded on ultrasound revealed a corresponding recovery to normal in the hemoglobin concentration images, whereas the nonresponder indicated an increase in hemoglobin concentration in the tumor compared to her pretreatment images. These case studies suggest that optical imaging of the breast during neoadjuvant hormone treatment can provide potentially valuable information, and that physiological changes within the tumor can be seen in response to treatment.
KW - diffuse optical tomography
KW - optical mammography
KW - response to therapy
UR - http://www.scopus.com/inward/record.url?scp=84886796029&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.18.5.056012
DO - 10.1117/1.JBO.18.5.056012
M3 - Article
C2 - 23698285
AN - SCOPUS:84886796029
SN - 1083-3668
VL - 18
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 5
M1 - 056012
ER -
