Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

on behalf of the Precision Surgery Group at the NIHR Oncology Translational Research Collaboration

doi:10.3390/cancers16051045

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

on behalf of the Precision Surgery Group at the NIHR Oncology Translational Research Collaboration

Imaging Chemistry & Biology

Cancer Section
UCL Great Ormond Street Institute of Child Health
UCL University College London
Great Ormond Street Hospital for Children NHS Foundation Trust
Policlinico of Milan
Bristol Medical School
North Bristol NHS Trust
Royal Marsden NHS Foundation Trust
Newcastle University
Royal Victoria Infirmary
Imperial College London
Department of Imaging Chemistry and Biology
St Thomas' Hospital

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

6 Downloads (Pure)

Abstract

This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available “off-the-shelf” injectable fluorescent probes for safer and more effective solid tumor resection.

Original language	English
Article number	1045
Journal	Cancers
Volume	16
Issue number	5
DOIs	https://doi.org/10.3390/cancers16051045
Publication status	Published - 3 Mar 2024

Keywords

fluorophores
monoclonal antibodies
solid malignancies
surgical oncology
targeted fluorescence-guided surgery

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10.3390/cancers16051045Licence: CC BY

Monoclonal Antibodies_VoRFinal published version, 1.7 MBLicence: CC BY

Cite this

@article{b696685949984c8a8cce46fe0c7d5df9,

title = "Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors",

abstract = "This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available “off-the-shelf” injectable fluorescent probes for safer and more effective solid tumor resection.",

keywords = "fluorophores, monoclonal antibodies, solid malignancies, surgical oncology, targeted fluorescence-guided surgery",

author = "Stefano Giuliani and Irene Paraboschi and Angus McNair and Myles Smith and Rankin, \{Kenneth S.\} and Elson, \{Daniel S.\} and Vinidh Paleri and Daniel Leff and Graeme Stasiuk and John Anderson and \{on behalf of the Precision Surgery Group at the NIHR Oncology Translational Research Collaboration\}",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = mar,

day = "3",

doi = "10.3390/cancers16051045",

language = "English",

volume = "16",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "5",

}

TY - JOUR

T1 - Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery

T2 - A Review of Applicability across Multiple Solid Tumors

AU - Giuliani, Stefano

AU - Paraboschi, Irene

AU - McNair, Angus

AU - Smith, Myles

AU - Rankin, Kenneth S.

AU - Elson, Daniel S.

AU - Paleri, Vinidh

AU - Leff, Daniel

AU - Stasiuk, Graeme

AU - Anderson, John

AU - on behalf of the Precision Surgery Group at the NIHR Oncology Translational Research Collaboration

PY - 2024/3/3

Y1 - 2024/3/3

N2 - This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available “off-the-shelf” injectable fluorescent probes for safer and more effective solid tumor resection.

AB - This study aims to review the status of the clinical use of monoclonal antibodies (mAbs) that have completed or are in ongoing clinical trials for targeted fluorescence-guided surgery (T-FGS) for the intraoperative identification of the tumor margins of extra-hematological solid tumors. For each of them, the targeted antigen, the mAb generic/commercial name and format, and clinical indications are presented, together with utility, doses, and the timing of administration. Based on the current scientific evidence in humans, the top three mAbs that could be prepared in a GMP-compliant bank ready to be delivered for surgical purposes are proposed to speed up the translation to the operating room and produce a few readily available “off-the-shelf” injectable fluorescent probes for safer and more effective solid tumor resection.

KW - fluorophores

KW - monoclonal antibodies

KW - solid malignancies

KW - surgical oncology

KW - targeted fluorescence-guided surgery

UR - https://www.scopus.com/pages/publications/85187894198

U2 - 10.3390/cancers16051045

DO - 10.3390/cancers16051045

M3 - Review article

AN - SCOPUS:85187894198

SN - 2072-6694

VL - 16

JO - Cancers

JF - Cancers

IS - 5

M1 - 1045

ER -

Monoclonal Antibodies for Targeted Fluorescence-Guided Surgery: A Review of Applicability across Multiple Solid Tumors

Abstract

Keywords

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