Monolith-based 68Ga processing: A new strategy for purification to facilitate direct radiolabelling methods

Ping He; Benjamin P. Burke; Gonçalo S. Clemente; Nathan Brown; Nicole Pamme; Stephen J. Archibald

doi:10.1039/c6re00081a

Monolith-based ⁶⁸Ga processing: A new strategy for purification to facilitate direct radiolabelling methods

Ping He, Benjamin P. Burke, Gonçalo S. Clemente, Nathan Brown, Nicole Pamme, Stephen J. Archibald

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The post-processing of ⁶⁸Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified ⁶⁸Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.

Original language	English
Pages (from-to)	361-365
Number of pages	5
Journal	Reaction Chemistry and Engineering
Volume	1
Issue number	4
DOIs	https://doi.org/10.1039/c6re00081a
Publication status	Published - Aug 2016

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abstract = "The post-processing of 68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified 68Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.",

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AU - Brown, Nathan

AU - Pamme, Nicole

AU - Archibald, Stephen J.

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AB - The post-processing of 68Ga generator eluate by means of a novel high capacity cation-exchange silica monolith column has been validated in this work. Quantitative release of a purified 68Ga solution in high concentration can be achieved using weak acidic solutions which can be directly used for chelator or conjugate labelling in an injectable form with improved radiochemical characteristics. The system has the potential to be incorporated in a flow based microfluidic system for dose-on-demand radiotracer synthesis.

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Monolith-based ⁶⁸Ga processing: A new strategy for purification to facilitate direct radiolabelling methods

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