More alive than dead: Non-apoptotic roles for caspases in neuronal development, plasticity and disease

Amrita Mukherjee; Darren W. Williams

doi:10.1038/cdd.2017.64

More alive than dead: Non-apoptotic roles for caspases in neuronal development, plasticity and disease

Amrita Mukherjee, Darren W. Williams^*

^*Corresponding author for this work

Developmental Neurobiology

King's College London

Research output: Contribution to journal › Review article › peer-review

67 Citations (Scopus)

Abstract

Nervous systems are arguably the most fascinating and complex structures in the known universe. How they are built, changed by experience and then degenerate are some of the biggest questions in biology. Regressive phenomena, such as neuron pruning and programmed cell death, have a key role in the building and maintenance of the nervous systems. Both of these cellular mechanisms deploy the caspase family of protease enzymes. In this review, we highlight the non-apoptotic function of caspases during nervous system development, plasticity and disease, particularly focussing on their role in structural remodelling. We have classified pruning as either macropruning, where complete branches are removed, or micropruning, where individual synapses or dendritic spines are eliminated. Finally we discuss open questions and possible future directions within the field.

Original language	English
Pages (from-to)	1411-1421
Number of pages	11
Journal	CELL DEATH AND DIFFERENTIATION
Volume	24
Issue number	8
DOIs	https://doi.org/10.1038/cdd.2017.64
Publication status	Published - 1 Aug 2017

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10.1038/cdd.2017.64

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More alive than dead: Non-apoptotic roles for caspases in neuronal development, plasticity and disease

Abstract

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