Mortality in Relation to Changes in a Healthy Aging Index: The Health, Aging and Body Composition Study

Matthew David Liam O'Connell, Megan Marron, Robert Boudreau, Mark Canney, Rose Anne Kenny, Stephen Kritchevsky, Tamara Harris, Anne Newman

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Baseline scores on a Healthy Aging Index (HAI), including 5 key physiological domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality.

Data are from the Health, Aging and Body Composition study of well-functioning adults aged 70-79. A HAI, which ranges from 0-10, was constructed at year 1 and year 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C and fasting glucose. The relationships between the HAI at year 1 and year 10 and the change between years and subsequent mortality until year 17 were estimated from Cox proportional hazards models.

2264 participants had complete data on a HAI at year 1, of these 1122 had complete data at year 10. HAI scores tended to increase (i.e., get worse) over 9-year follow-up, from (mean (SD)) 4.3 (2.1) to 5.7 (2.1); mean within person change 1.5 (1.6). After multivariable adjustment HAI score was related to mortality from year 1 (Hazard Ratio (95% Confidence Interval) =1.17 (1.13 - 1.21) per unit) and year 10 (1.20 (1.14 - 1.27) per unit). The change between years was also related to mortality (1.08 (1.02 - 1.15) per unit change).

HAI scores tended to increase with advancing age and stratified mortality rates among participants remaining at year 10. The HAI may prove useful to understand changes in health with aging
Original languageEnglish
JournalJournals of Gerontology Series. A, Biological Sciences and Medical Sciences
Publication statusE-pub ahead of print - 4 May 2018


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