Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse

Alessandra Biaggi; Katie Hazelgrove; Freddie Waites; Rebecca H Bind; Andrew J Lawrence; Montserrat Fuste; Susan Conroy; Louise M Howard; Mitul A Mehta; Maddalena Miele; Gertrude Seneviratne; Susan Pawlby; Carmine M Pariante; Paola Dazzan

doi:10.1017/S0033291723002568

Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse

Alessandra Biaggi, Katie Hazelgrove, Freddie Waites, Rebecca H Bind, Andrew J Lawrence, Montserrat Fuste, Susan Conroy, Louise M Howard, Mitul A Mehta, Maddalena Miele, Gertrude Seneviratne, Susan Pawlby, Carmine M Pariante, Paola Dazzan

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

BACKGROUND: This study aimed to investigate mother-infant interaction and infant development in women at-risk of postpartum psychosis (PP), with and without a postpartum relapse.

METHODS: 103 women (and their offspring) were included, 43 at-risk-of-PP because of a diagnosis of bipolar disorder, schizoaffective disorder or previous PP, and 60 with no current/previous mental illness or family history of PP. Of the at-risk women, 18 developed a psychiatric relapse within 4 weeks after delivery (AR-unwell), while 25 remained symptom-free (AR-well). Mother-infant interaction was assessed using the CARE-Index at 8 weeks' and 12 months' postpartum and infant development using the Bayley-III at 12 months' postpartum.

RESULTS: Women at-risk-of-PP as a group, regardless of whether they developed a psychiatric relapse within 4 weeks after delivery, had less synchronous mother-infant interactions and had infants with less optimal cognitive, language, motor and socio-emotional development than healthy controls. In particular, boys of at-risk women had the lowest scores in cognitive, language and motor development and in mother-infant interaction, while girls of the at-risk women had the lowest scores in socio-emotional development. The synchrony in the dyad predicted infant cognitive and language development. There was no evidence for a difference in mother-infant interaction nor in infant development between the AR-unwell and AR-well groups.

CONCLUSIONS: These results suggest that, while there is a lack of evidence that an early postpartum relapse in women at-risk-of-PP could represent a risk for the infant per se, maternal risk for PP may be associated with less optimal mother-infant interaction and infant development.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Psychological Medicine
Early online date	14 Sept 2023
DOIs	https://doi.org/10.1017/S0033291723002568
Publication status	E-pub ahead of print - 14 Sept 2023

Access to Document

10.1017/S0033291723002568

Cite this

Biaggi, A., Hazelgrove, K., Waites, F., Bind, R. H., Lawrence, A. J., Fuste, M., Conroy, S., Howard, L. M., Mehta, M. A., Miele, M., Seneviratne, G., Pawlby, S., Pariante, C. M., & Dazzan, P. (2023). Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse. Psychological Medicine, 1-12. Advance online publication. https://doi.org/10.1017/S0033291723002568

@article{ed91a6668fd34ffaac810eb0b70d4bbd,

title = "Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse",

abstract = "BACKGROUND: This study aimed to investigate mother-infant interaction and infant development in women at-risk of postpartum psychosis (PP), with and without a postpartum relapse.METHODS: 103 women (and their offspring) were included, 43 at-risk-of-PP because of a diagnosis of bipolar disorder, schizoaffective disorder or previous PP, and 60 with no current/previous mental illness or family history of PP. Of the at-risk women, 18 developed a psychiatric relapse within 4 weeks after delivery (AR-unwell), while 25 remained symptom-free (AR-well). Mother-infant interaction was assessed using the CARE-Index at 8 weeks' and 12 months' postpartum and infant development using the Bayley-III at 12 months' postpartum.RESULTS: Women at-risk-of-PP as a group, regardless of whether they developed a psychiatric relapse within 4 weeks after delivery, had less synchronous mother-infant interactions and had infants with less optimal cognitive, language, motor and socio-emotional development than healthy controls. In particular, boys of at-risk women had the lowest scores in cognitive, language and motor development and in mother-infant interaction, while girls of the at-risk women had the lowest scores in socio-emotional development. The synchrony in the dyad predicted infant cognitive and language development. There was no evidence for a difference in mother-infant interaction nor in infant development between the AR-unwell and AR-well groups.CONCLUSIONS: These results suggest that, while there is a lack of evidence that an early postpartum relapse in women at-risk-of-PP could represent a risk for the infant per se, maternal risk for PP may be associated with less optimal mother-infant interaction and infant development.",

author = "Alessandra Biaggi and Katie Hazelgrove and Freddie Waites and Bind, {Rebecca H} and Lawrence, {Andrew J} and Montserrat Fuste and Susan Conroy and Howard, {Louise M} and Mehta, {Mitul A} and Maddalena Miele and Gertrude Seneviratne and Susan Pawlby and Pariante, {Carmine M} and Paola Dazzan",

note = "Funding Information: PD has received speaker's fees from Lundbeck and Janssen. CMP has received research funding from Johnson & Johnson for research on depression and inflammation and is funded by the Wellcome Trust strategy award to the Neuroimmunology of Mood Disorders and Alzheimer's Disease (NIMA) Consortium (104025), which is also funded by Janssen, GlaxoSmithKline, Lundbeck and Pfizer. LMH has received funding from the NIHR and the Nuffield Foundation for Research Programmes on maternal mental disorders. MAM has received research funding from Takeda Pharmaceuticals, Lundbeck, Johnson & Johnson and support in kind from AstraZeneca and has acted as a consultant for Lundbeck and Takeda. However, this paper is independent from this funding; there are no further declarations of interest. Funding Information: This work was supported by the Medical Research Foundation [grant number C0439] and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. CMP is a NIHR Senior Investigator. The funding sources played no role in the study design, collection, analysis or interpretation of findings, in writing the report or in the decision to submit the article for publication. Publisher Copyright: Copyright {\textcopyright} The Author(s), 2023. Published by Cambridge University Press.",

year = "2023",

month = sep,

day = "14",

doi = "10.1017/S0033291723002568",

language = "English",

pages = "1--12",

journal = "Psychological Medicine",

issn = "0033-2917",

publisher = "Cambridge University Press",

}

Biaggi, A , Hazelgrove, K , Waites, F , Bind, RH , Lawrence, AJ , Fuste, M , Conroy, S , Howard, LM , Mehta, MA, Miele, M, Seneviratne, G , Pawlby, S , Pariante, CM & Dazzan, P 2023, 'Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse', Psychological Medicine, pp. 1-12. https://doi.org/10.1017/S0033291723002568

TY - JOUR

T1 - Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse

AU - Biaggi, Alessandra

AU - Hazelgrove, Katie

AU - Waites, Freddie

AU - Bind, Rebecca H

AU - Lawrence, Andrew J

AU - Fuste, Montserrat

AU - Conroy, Susan

AU - Howard, Louise M

AU - Mehta, Mitul A

AU - Miele, Maddalena

AU - Seneviratne, Gertrude

AU - Pawlby, Susan

AU - Pariante, Carmine M

AU - Dazzan, Paola

N1 - Funding Information: PD has received speaker's fees from Lundbeck and Janssen. CMP has received research funding from Johnson & Johnson for research on depression and inflammation and is funded by the Wellcome Trust strategy award to the Neuroimmunology of Mood Disorders and Alzheimer's Disease (NIMA) Consortium (104025), which is also funded by Janssen, GlaxoSmithKline, Lundbeck and Pfizer. LMH has received funding from the NIHR and the Nuffield Foundation for Research Programmes on maternal mental disorders. MAM has received research funding from Takeda Pharmaceuticals, Lundbeck, Johnson & Johnson and support in kind from AstraZeneca and has acted as a consultant for Lundbeck and Takeda. However, this paper is independent from this funding; there are no further declarations of interest. Funding Information: This work was supported by the Medical Research Foundation [grant number C0439] and the National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London. CMP is a NIHR Senior Investigator. The funding sources played no role in the study design, collection, analysis or interpretation of findings, in writing the report or in the decision to submit the article for publication. Publisher Copyright: Copyright © The Author(s), 2023. Published by Cambridge University Press.

PY - 2023/9/14

Y1 - 2023/9/14

N2 - BACKGROUND: This study aimed to investigate mother-infant interaction and infant development in women at-risk of postpartum psychosis (PP), with and without a postpartum relapse.METHODS: 103 women (and their offspring) were included, 43 at-risk-of-PP because of a diagnosis of bipolar disorder, schizoaffective disorder or previous PP, and 60 with no current/previous mental illness or family history of PP. Of the at-risk women, 18 developed a psychiatric relapse within 4 weeks after delivery (AR-unwell), while 25 remained symptom-free (AR-well). Mother-infant interaction was assessed using the CARE-Index at 8 weeks' and 12 months' postpartum and infant development using the Bayley-III at 12 months' postpartum.RESULTS: Women at-risk-of-PP as a group, regardless of whether they developed a psychiatric relapse within 4 weeks after delivery, had less synchronous mother-infant interactions and had infants with less optimal cognitive, language, motor and socio-emotional development than healthy controls. In particular, boys of at-risk women had the lowest scores in cognitive, language and motor development and in mother-infant interaction, while girls of the at-risk women had the lowest scores in socio-emotional development. The synchrony in the dyad predicted infant cognitive and language development. There was no evidence for a difference in mother-infant interaction nor in infant development between the AR-unwell and AR-well groups.CONCLUSIONS: These results suggest that, while there is a lack of evidence that an early postpartum relapse in women at-risk-of-PP could represent a risk for the infant per se, maternal risk for PP may be associated with less optimal mother-infant interaction and infant development.

AB - BACKGROUND: This study aimed to investigate mother-infant interaction and infant development in women at-risk of postpartum psychosis (PP), with and without a postpartum relapse.METHODS: 103 women (and their offspring) were included, 43 at-risk-of-PP because of a diagnosis of bipolar disorder, schizoaffective disorder or previous PP, and 60 with no current/previous mental illness or family history of PP. Of the at-risk women, 18 developed a psychiatric relapse within 4 weeks after delivery (AR-unwell), while 25 remained symptom-free (AR-well). Mother-infant interaction was assessed using the CARE-Index at 8 weeks' and 12 months' postpartum and infant development using the Bayley-III at 12 months' postpartum.RESULTS: Women at-risk-of-PP as a group, regardless of whether they developed a psychiatric relapse within 4 weeks after delivery, had less synchronous mother-infant interactions and had infants with less optimal cognitive, language, motor and socio-emotional development than healthy controls. In particular, boys of at-risk women had the lowest scores in cognitive, language and motor development and in mother-infant interaction, while girls of the at-risk women had the lowest scores in socio-emotional development. The synchrony in the dyad predicted infant cognitive and language development. There was no evidence for a difference in mother-infant interaction nor in infant development between the AR-unwell and AR-well groups.CONCLUSIONS: These results suggest that, while there is a lack of evidence that an early postpartum relapse in women at-risk-of-PP could represent a risk for the infant per se, maternal risk for PP may be associated with less optimal mother-infant interaction and infant development.

UR - http://www.scopus.com/inward/record.url?scp=85171536338&partnerID=8YFLogxK

U2 - 10.1017/S0033291723002568

DO - 10.1017/S0033291723002568

M3 - Article

C2 - 37706314

SN - 0033-2917

SP - 1

EP - 12

JO - Psychological Medicine

JF - Psychological Medicine

ER -

Mother-infant interaction and infant development in women at risk of postpartum psychosis with and without a postpartum relapse

Abstract

Access to Document

Other files and links

Fingerprint

Cite this