Motion corrected fetal body magnetic resonance imaging provides reliable 3D lung volumes in normal and abnormal fetuses

TY - JOUR

T1 - Motion corrected fetal body magnetic resonance imaging provides reliable 3D lung volumes in normal and abnormal fetuses

AU - Davidson, Joseph

AU - Uus, Alena

AU - Egloff, Alexia

AU - van Poppel, Milou

AU - Matthew, Jacqueline

AU - Steinweg, Johannes

AU - Deprez, Maria

AU - Aertsen, Michael

AU - Deprest, Jan

AU - Rutherford, Mary

N1 - Funding Information: The iFIND study, from which these cases are derived, was supported by a Wellcome Trust IEH Award (102431). Research carried out at King's College London is made possible by NIHR funding of the Biomedical Research Centre; the views expressed here are those of the authors and not necessarily those of the NHS, NIHR or DoH. This study received no specific internal or external funding. Funding Information: The iFIND study, from which these cases are derived, was supported by a Wellcome Trust IEH Award (102431). Research carried out at King's College London is made possible by NIHR funding of the Biomedical Research Centre; the views expressed here are?those of the authors and not necessarily those of the NHS, NIHR or DoH. This study received no specific internal or external funding. Publisher Copyright: © 2022 The Authors. Prenatal Diagnosis published by John Wiley & Sons Ltd.

PY - 2022/5

Y1 - 2022/5

N2 - Objectives: To calculate 3D-segmented total lung volume (TLV) in fetuses with thoracic anomalies using deformable slice-to-volume registration (DSVR) with comparison to 2D-manual segmentation. To establish a normogram of TLV calculated by DSVR in healthy control fetuses. Methods: A pilot study at a single regional fetal medicine referral centre included 16 magnetic resonance imaging (MRI) datasets of fetuses (22–32 weeks gestational age). Diagnosis was CDH (n = 6), CPAM (n = 2), and healthy controls (n = 8). Deformable slice-to-volume registration was used for reconstruction of 3D isotropic (0.85 mm) volumes of the fetal body followed by semi-automated lung segmentation. 3D TLV were compared to traditional 2D-based volumetry. Abnormal cases referenced to a normogram produced from 100 normal fetuses whose TLV was calculated by DSVR only. Results: Deformable slice-to-volume registration-derived TLV values have high correlation with the 2D-based measurements but with a consistently lower volume; bias −1.44 cm3 [95% limits: −2.6 to −0.3] with improved resolution to exclude hilar structures even in cases of motion corruption or very low lung volumes. Conclusions: Deformable slice-to-volume registration for fetal lung MRI aids analysis of motion corrupted scans and does not suffer from the interpolation error inherent to 2D-segmentation. It increases information content of acquired data in terms of visualising organs in 3D space and quantification of volumes, which may improve counselling and surgical planning.

AB - Objectives: To calculate 3D-segmented total lung volume (TLV) in fetuses with thoracic anomalies using deformable slice-to-volume registration (DSVR) with comparison to 2D-manual segmentation. To establish a normogram of TLV calculated by DSVR in healthy control fetuses. Methods: A pilot study at a single regional fetal medicine referral centre included 16 magnetic resonance imaging (MRI) datasets of fetuses (22–32 weeks gestational age). Diagnosis was CDH (n = 6), CPAM (n = 2), and healthy controls (n = 8). Deformable slice-to-volume registration was used for reconstruction of 3D isotropic (0.85 mm) volumes of the fetal body followed by semi-automated lung segmentation. 3D TLV were compared to traditional 2D-based volumetry. Abnormal cases referenced to a normogram produced from 100 normal fetuses whose TLV was calculated by DSVR only. Results: Deformable slice-to-volume registration-derived TLV values have high correlation with the 2D-based measurements but with a consistently lower volume; bias −1.44 cm3 [95% limits: −2.6 to −0.3] with improved resolution to exclude hilar structures even in cases of motion corruption or very low lung volumes. Conclusions: Deformable slice-to-volume registration for fetal lung MRI aids analysis of motion corrupted scans and does not suffer from the interpolation error inherent to 2D-segmentation. It increases information content of acquired data in terms of visualising organs in 3D space and quantification of volumes, which may improve counselling and surgical planning.

UR - http://www.scopus.com/inward/record.url?scp=85126208625&partnerID=8YFLogxK

U2 - 10.1002/pd.6129

DO - 10.1002/pd.6129

M3 - Article

C2 - 35262959

AN - SCOPUS:85126208625

SN - 0197-3851

VL - 42

SP - 628

EP - 635

JO - Prenatal Diagnosis

JF - Prenatal Diagnosis

IS - 5

ER -