Objectives: To calculate 3D-segmented total lung volume (TLV) in fetuses with thoracic anomalies using deformable slice-to-volume registration (DSVR) with comparison to 2D-manual segmentation. To establish normogram of TLV calculated by DSVR in healthy control fetuses.
Methods: A pilot study at a single regional fetal medicine referral centre included 16 MRI datasets of fetuses (22-32 weeks GA). Diagnosis was CDH(n=6), CPAM(n=2), and healthy controls(n=8). DSVR was used for reconstruction of 3D isotropic (0.85 mm) volumes of the fetal body followed by semi-automated lung segmentation. 3D TLV were compared to traditional 2D-based volumetry. Abnormal cases referenced to a normogram produced from 100 normal fetuses whose TLV was calculated by DSVR only.
Results: DSVR-derived TLV values have high correlation with the 2D-based measurements but with a consistently lower volume; bias -1.44cm3 [95%limits: -2.6 to -0.3] with improved resolution to exclude hilar structures even in cases of motion corruption or very low lung volumes.
Conclusions: DSVR for fetal lung MRI aids analysis of motion corrupted scans and does not suffer from the interpolation error inherent to 2D-segmentation. It increases information content of acquired data in terms of visualising organs in 3D space and quantification of volumes, which may improve counselling and surgical planning.
Original languageEnglish
JournalPrenatal Diagnosis
Publication statusAccepted/In press - 26 Feb 2022


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