MR Fingerprinting for Contrast Agent-free and Quantitative Characterization of Focal Liver Lesions

Shohei Fujita, Katsuhiro Sano, Gastao Cruz, Carlos Velasco, Hideo Kawasaki, Yuki Fukumura, Masami Yoneyama, Akiyoshi Suzuki, Kotaro Yamamoto, Yuichi Morita, Takashi Arai, Issei Fukunaga, Wataru Uchida, Koji Kamagata, Osamu Abe, Ryohei Kuwatsuru, Akio Saiura, Kenichi Ikejima, René Botnar, Claudia PrietoShigeki Aoki

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Purpose: lesions. To evaluate the feasibility of liver MR fingerprinting (MRF) for quantitative characterization and diagnosis of focal liver Materials and Methods: This single-site, prospective study included 89 participants (mean age, 62 years ± 15 [SD]; 45 women, 44 men) with various focal liver lesions who underwent MRI between October 2021 and August 2022. The participants underwent routine clinical MRI, non–contrast-enhanced liver MRF, and reference quantitative MRI with a 1.5-T MRI scanner. The bias and repeatability of the MRF measurements were assessed using linear regression, Bland-Altman plots, and coefficients of variation. The diagnostic capa-bility of MRF-derived T1, T2, T2*, proton density fat fraction (PDFF), and a combination of these metrics to distinguish benign from malignant lesions was analyzed according to the area under the receiver operating characteristic curve (AUC). Results: Liver MRF measurements showed moderate to high agreement with reference measurements (intraclass correlation = 0.94, 0.77, 0.45, and 0.61 for T1, T2, T2*, and PDFF, respectively), with underestimation of T2 values (mean bias in lesion = −0.5%, −29%, 5.8%, and −8.2% for T1, T2, T2*, and PDFF, respectively). The median coefficients of variation for repeatability of T1, T2, and T2* values were 2.5% (IQR, 3.6%), 3.1% (IQR, 5.6%), and 6.6% (IQR, 13.9%), respectively. After considering multicollinearity, a combination of MRF measurements showed a high diagnostic performance in differentiating benign from malignant lesions (AUC = 0.92 [95% CI: 0.86, 0.98]). Conclusion: Liver MRF enabled the quantitative characterization of various focal liver lesions in a single breath-hold acquisition.

Original languageEnglish
Article numbere230036
Pages (from-to)e230036
JournalRadiology. Imaging cancer
Volume5
Issue number6
DOIs
Publication statusPublished - Nov 2023

Cite this