MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE

Y L  CHUNG; A  WILLIAMS; J S  BEECH; S C R  WILLIAMS; J D  BELL; I J  COX; J  HOPE

doi:10.1006/neur.1995.0025

MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE

Y L CHUNG, A WILLIAMS, J S BEECH, S C R WILLIAMS, J D BELL, I J COX, J HOPE

Hammersmith Hospital

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21 Citations (Scopus)

Abstract

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DPTA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results that blood-brain barrier function is disrupted in the clinically-affected animal.

Original language	English
Pages (from-to)	203-207
Number of pages	5
Journal	Neurodegeneration
Volume	4
Issue number	2
DOIs	https://doi.org/10.1006/neur.1995.0025
Publication status	Published - Jun 1995

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title = "MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE",

abstract = "Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DPTA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results that blood-brain barrier function is disrupted in the clinically-affected animal.",

author = "CHUNG, {Y L} and A WILLIAMS and BEECH, {J S} and WILLIAMS, {S C R} and BELL, {J D} and COX, {I J} and J HOPE",

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AU - WILLIAMS, S C R

AU - BELL, J D

AU - COX, I J

AU - HOPE, J

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N2 - Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DPTA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results that blood-brain barrier function is disrupted in the clinically-affected animal.

AB - Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DPTA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results that blood-brain barrier function is disrupted in the clinically-affected animal.

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DO - 10.1006/neur.1995.0025

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JO - Neurodegeneration

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IS - 2

ER -

MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE

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