MRI contrast agent delivery using spore capsules: Controlled release in blood plasma

Mark Lorch; Matthew J. Thomasson; Alberto Diego-Taboada; Sylvain Barrier; Stephen L. Atkin; Grahame MacKenzie; Stephen J. Archibald

doi:10.1039/b909551a

MRI contrast agent delivery using spore capsules: Controlled release in blood plasma

Mark Lorch, Matthew J. Thomasson, Alberto Diego-Taboada, Sylvain Barrier, Stephen L. Atkin, Grahame MacKenzie, Stephen J. Archibald

Imaging Chemistry & Biology

Research output: Contribution to journal › Article › peer-review

56 Citations (Scopus)

Abstract

The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(iii) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

Original language	English
Pages (from-to)	6442-6444
Number of pages	3
Journal	Chemical Communications
Issue number	42
DOIs	https://doi.org/10.1039/b909551a
Publication status	Published - 2009

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10.1039/b909551a

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title = "MRI contrast agent delivery using spore capsules: Controlled release in blood plasma",

abstract = "The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(iii) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.",

author = "Mark Lorch and Thomasson, {Matthew J.} and Alberto Diego-Taboada and Sylvain Barrier and Atkin, {Stephen L.} and Grahame MacKenzie and Archibald, {Stephen J.}",

year = "2009",

doi = "10.1039/b909551a",

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T2 - Controlled release in blood plasma

AU - Lorch, Mark

AU - Thomasson, Matthew J.

AU - Diego-Taboada, Alberto

AU - Barrier, Sylvain

AU - Atkin, Stephen L.

AU - MacKenzie, Grahame

AU - Archibald, Stephen J.

PY - 2009

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AB - The exine coatings of spores can be used to encapsulate drug molecules. We have demonstrated that these microcapsules can be filled with a commercial gadolinium(iii) MRI contrast agent (in this proof of concept study Gd-DTPA-BMA was used) which is slowly released in plasma due to enzymatic digestion of the capsule.

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SN - 1359-7345

SP - 6442

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JO - Chemical Communications

JF - Chemical Communications

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ER -

MRI contrast agent delivery using spore capsules: Controlled release in blood plasma

Abstract

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