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MRI in head and neck cancer following chemoradiotherapy: what is the optimal delay to demonstrate maximal response?

Research output: Contribution to journalArticlepeer-review

Steve Connor, Christian Burd, Nishanth Sivarasan, Vicky Goh

Original languageEnglish
Pages (from-to)9273-9286
Number of pages14
JournalEuropean Radiology
Volume31
Issue number12
Early online date19 May 2021
DOIs
Accepted/In press23 Feb 2021
E-pub ahead of print19 May 2021
PublishedDec 2021

Bibliographical note

Funding Information: The authors would like to thank Guy’s and St Thomas’ Hospital Charity (ref EFT130501) and the Royal College of Radiologists (Kodak Radiology Fund Research Bursary) for the funding of this study. Publisher Copyright: © 2021, Crown.

King's Authors

Abstract

Objectives: To investigate the optimal timing for post-chemoradiotherapy (CRT) reference magnetic resonance imaging (MRI) in head and neck cancer, so as to demonstrate a maximal treatment response. To assess whether this differs in human papillomavirus–related oropharyngeal cancer (HPV-OPC) and whether the MRI timing impacts on the ability to predict treatment success. Methods: Following ethical approval and informed consent, 45 patients (40 male, mean age 59.7 ± 7.9 years, 33 HPV-OPC) with stage 3 and 4 HNSCC underwent pre-treatment, 6- and 12-week post-CRT MRIs in this prospective cohort study. Primary tumour (n = 39) size, T2w morphology and diffusion weight imaging (DWI) scores, together with nodal (n = 42) size and necrotic/cystic change, were recorded. Interval imaging changes were analysed for all patients and according to HPV-OPC status. MRI descriptors and their interval changes were also compared with 2-year progression-free survival (PFS). Results: All MRI descriptors significantly changed between pre-treatment and 6-week post-treatment MRI studies (p <.001). Primary tumour and nodal volume decreased between 6- and 12-week studies; however, interval changes in linear dimensions were only evident for HPV-OPC lymph nodes. Nodal necrosis scores also evolved after 6 weeks but other descriptors were stable. The 6-week nodal necrosis score and the 6- and 12-week nodal volume were predictive of 2-year PFS. Conclusion: Apart from HPV-OPC patients with nodal disease, the 6-week post-CRT MRI demonstrates maximal reduction in the linear dimensions of head and neck cancer; however, a later reference study should be considered if volumetric analysis is applied. Key Points: • This study provides guidance on when early post-treatment imaging should be performed in head and neck cancer following chemoradiotherapy, in order to aid subsequent detection of recurrent tumour. • Lymph nodes in HPV-related oropharyngeal cancer patients clearly reduced in size from 6 to 12 weeks post-treatment. However, other lymph node disease and all primary tumours showed only a minor reduction in size beyond 6 weeks, and this required a detailed volumetric analysis for demonstration. • Timing of the reference MRI following chemoradiotherapy for head and neck cancer depends on whether the patient has HPV-related oropharyngeal cancer and whether there is nodal disease. MRI as early as 6 weeks post-treatment may be performed unless volumetric analysis is routinely performed.

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