MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency

Rosalind Aughwane; Magdalena Sokolska; Alan Bainbridge; David Atkinson; Giles Kendall; Jan Deprest; Tom Vercauteren; Anna L. David; Sébastien Ourselin; Andrew Melbourne

doi:10.1007/978-3-030-00934-2_101

MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency

Rosalind Aughwane, Magdalena Sokolska, Alan Bainbridge, David Atkinson, Giles Kendall, Jan Deprest, Tom Vercauteren, Anna L. David, Sébastien Ourselin, Andrew Melbourne^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

3 Citations (Scopus)

Abstract

The placenta is essential for successful pregnancy outcome. Inadequate placenta development leads to poor placental perfusion and placental insufficiency, responsible for one third of antenatal stillbirths. Current imaging modalities provide poor clinical assessment of placental perfusion and pregnancy outcome. In this work we propose a technique to estimate the vascular properties of retro-placenta myometrial and placental perfusion. The fetal blood saturation is a relative unknown, thus we describe a method to simultaneously estimate the fetal blood volume in addition to the fetal blood T2 relaxation time from which we can estimate this parameter. This information may prove useful for predicting if and when a placenta will fail, and thus when a small baby must be delivered to have the best neurological outcome. We report differences in vascular compartments and saturation values observed between 5 normal pregnancies, and two complicated by placental insufficiency.

Original language	English
Title of host publication	Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings
Editors	Gabor Fichtinger, Christos Davatzikos, Carlos Alberola-López, Alejandro F. Frangi, Julia A. Schnabel
Publisher	Springer Verlag
Pages	913-920
Number of pages	8
Volume	11071
ISBN (Print)	978-3-030-00933-5
DOIs	https://doi.org/10.1007/978-3-030-00934-2_101
Publication status	Published - 2018
Event	21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018 - Granada, Spain Duration: 16 Sept 2018 → 20 Sept 2018

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	11071 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Conference

Conference	21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018
Country/Territory	Spain
City	Granada
Period	16/09/2018 → 20/09/2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/978-3-030-00934-2_101

Cite this

Aughwane, R., Sokolska, M., Bainbridge, A., Atkinson, D., Kendall, G., Deprest, J., Vercauteren, T., David, A. L., Ourselin, S., & Melbourne, A. (2018). MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency. In G. Fichtinger, C. Davatzikos, C. Alberola-López, A. F. Frangi, & J. A. Schnabel (Eds.), Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings (Vol. 11071, pp. 913-920). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11071 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-030-00934-2_101

Aughwane, Rosalind ; Sokolska, Magdalena ; Bainbridge, Alan et al. / MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency. Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. editor / Gabor Fichtinger ; Christos Davatzikos ; Carlos Alberola-López ; Alejandro F. Frangi ; Julia A. Schnabel. Vol. 11071 Springer Verlag, 2018. pp. 913-920 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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title = "MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency",

abstract = "The placenta is essential for successful pregnancy outcome. Inadequate placenta development leads to poor placental perfusion and placental insufficiency, responsible for one third of antenatal stillbirths. Current imaging modalities provide poor clinical assessment of placental perfusion and pregnancy outcome. In this work we propose a technique to estimate the vascular properties of retro-placenta myometrial and placental perfusion. The fetal blood saturation is a relative unknown, thus we describe a method to simultaneously estimate the fetal blood volume in addition to the fetal blood T2 relaxation time from which we can estimate this parameter. This information may prove useful for predicting if and when a placenta will fail, and thus when a small baby must be delivered to have the best neurological outcome. We report differences in vascular compartments and saturation values observed between 5 normal pregnancies, and two complicated by placental insufficiency.",

author = "Rosalind Aughwane and Magdalena Sokolska and Alan Bainbridge and David Atkinson and Giles Kendall and Jan Deprest and Tom Vercauteren and David, {Anna L.} and S{\'e}bastien Ourselin and Andrew Melbourne",

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Aughwane, R, Sokolska, M, Bainbridge, A, Atkinson, D, Kendall, G, Deprest, J, Vercauteren, T, David, AL, Ourselin, S & Melbourne, A 2018, MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency. in G Fichtinger, C Davatzikos, C Alberola-López, AF Frangi & JA Schnabel (eds), Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. vol. 11071, Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 11071 LNCS, Springer Verlag, pp. 913-920, 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018, Granada, Spain, 16/09/2018. https://doi.org/10.1007/978-3-030-00934-2_101

MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency. / Aughwane, Rosalind; Sokolska, Magdalena; Bainbridge, Alan et al.
Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. ed. / Gabor Fichtinger; Christos Davatzikos; Carlos Alberola-López; Alejandro F. Frangi; Julia A. Schnabel. Vol. 11071 Springer Verlag, 2018. p. 913-920 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 11071 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

TY - CHAP

T1 - MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency

AU - Aughwane, Rosalind

AU - Sokolska, Magdalena

AU - Bainbridge, Alan

AU - Atkinson, David

AU - Kendall, Giles

AU - Deprest, Jan

AU - Vercauteren, Tom

AU - David, Anna L.

AU - Ourselin, Sébastien

AU - Melbourne, Andrew

PY - 2018

Y1 - 2018

N2 - The placenta is essential for successful pregnancy outcome. Inadequate placenta development leads to poor placental perfusion and placental insufficiency, responsible for one third of antenatal stillbirths. Current imaging modalities provide poor clinical assessment of placental perfusion and pregnancy outcome. In this work we propose a technique to estimate the vascular properties of retro-placenta myometrial and placental perfusion. The fetal blood saturation is a relative unknown, thus we describe a method to simultaneously estimate the fetal blood volume in addition to the fetal blood T2 relaxation time from which we can estimate this parameter. This information may prove useful for predicting if and when a placenta will fail, and thus when a small baby must be delivered to have the best neurological outcome. We report differences in vascular compartments and saturation values observed between 5 normal pregnancies, and two complicated by placental insufficiency.

AB - The placenta is essential for successful pregnancy outcome. Inadequate placenta development leads to poor placental perfusion and placental insufficiency, responsible for one third of antenatal stillbirths. Current imaging modalities provide poor clinical assessment of placental perfusion and pregnancy outcome. In this work we propose a technique to estimate the vascular properties of retro-placenta myometrial and placental perfusion. The fetal blood saturation is a relative unknown, thus we describe a method to simultaneously estimate the fetal blood volume in addition to the fetal blood T2 relaxation time from which we can estimate this parameter. This information may prove useful for predicting if and when a placenta will fail, and thus when a small baby must be delivered to have the best neurological outcome. We report differences in vascular compartments and saturation values observed between 5 normal pregnancies, and two complicated by placental insufficiency.

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DO - 10.1007/978-3-030-00934-2_101

M3 - Chapter

AN - SCOPUS:85054053979

SN - 978-3-030-00933-5

VL - 11071

T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)

SP - 913

EP - 920

BT - Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings

A2 - Fichtinger, Gabor

A2 - Davatzikos, Christos

A2 - Alberola-López, Carlos

A2 - Frangi, Alejandro F.

A2 - Schnabel, Julia A.

PB - Springer Verlag

T2 - 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018

Y2 - 16 September 2018 through 20 September 2018

ER -

Aughwane R, Sokolska M, Bainbridge A, Atkinson D, Kendall G, Deprest J et al. MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency. In Fichtinger G, Davatzikos C, Alberola-López C, Frangi AF, Schnabel JA, editors, Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings. Vol. 11071. Springer Verlag. 2018. p. 913-920. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/978-3-030-00934-2_101

MRI Measurement of Placental Perfusion and Fetal Blood Oxygen Saturation in Normal Pregnancy and Placental Insufficiency

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