Mucosal immunology in Candida albicans infection

Günther Weindl, Julian R. Naglik, David L. Moyes, Martin Schaller

    Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

    Abstract

    The human pathogenic fungus Candida albicans is the predominant cause of both superficial and invasive forms of candidiasis. Clinical observations suggest that mucocutaneous Candida infections are commonly associated with defective cell-mediated immune responses. The importance of the mucosal immune system as a first-line defence against pathogenic challenge has long been recognized. Over the last decade, the identity of many key molecules mediating host defence have been identified. Central to these developments is the discovery of pattern recognition receptors such as Toll-like receptors and C-type lectin receptors that induce innate immune responses and also modulate cellular and humoral adaptive immunity during Candida infections. We address the most relevant pattern recognition receptors and their signalling mechanisms in oral mucosa to gain a better understanding of their contributions to antifungal immunity at mucosal surfaces.

    Original languageEnglish
    Title of host publicationHuman Fungal Pathogens, 2nd Edition
    PublisherSpringer Berlin Heidelberg
    Pages161-176
    Number of pages16
    Volume12
    ISBN (Electronic)9783642394324
    ISBN (Print)9783642394317
    DOIs
    Publication statusPublished - 1 Jan 2014

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