In this work, we propose a methodology to generate a multi-channel (MC) continuous spatio-temporal parametrized atlas of the brain development that combines multiple MRI parameters during 37 to 44 weeks of postmenstrual age (PMA) in the same anatomical space. We co-align structural and diffusion MRI of 170 normal term subjects from the developing Human Connectomme Project using MC registration driven by both T2-weighted and orientation distribution functions (ODF) channels and fit the Gompertz model to the signals and spatial transformations in time. The resulting atlas consists of fourteen spatio-temporal microstructural indices and two parcellation maps delineating white matter tracts and neonatal transient structures.
In order to demonstrate applicability of the atlas for quantitative region-specific studies, a comparison analysis of 140 term and 40 preterm subjects scanned at the term-equivalent age was performed using different MRI-derived microstructural indices in the atlas reference space for multiple white matter regions, including the transient compartments. The atlas and software will be available after publication of the article.
|Number of pages||30|
|Journal||Frontiers in Neuroscience|
|Volume||Brain Imaging Methods|
|Publication status||Accepted/In press - 20 May 2021|
- Multi-modal MRI
- neonatal brain
- spatio-temporal atlas
- Atlas-based analysis
- Multi-channel registration
- White matter maturation
- white matter parcellation