Multi-vendor reliability of arterial spin labeling perfusion MRI using a near-identical sequence: Implications for multi-center studies

Henri J.m.m. Mutsaerts, Matthias J.p. Van Osch, Fernando O. Zelaya, Danny J.j. Wang, Wibeke Nordh??y, Yi Wang, Stephen Wastling, Maria A. Fernandez-seara, E.t. Petersen, Francesca B. Pizzini, Sameeha Fallatah, Jeroen Hendrikse, Oliver Geier, Matthias G??nther, Xavier Golay, Aart J. Nederveen, Atle Bj??rnerud, Inge R. Groote

Research output: Contribution to journalArticlepeer-review

66 Citations (Scopus)


IntroductionA main obstacle that impedes standardized clinical and research applications of arterial spin labeling (ASL), is the substantial differences between the commercial implementations of ASL from major MRI vendors. In this study, we compare a single identical 2D gradient-echo EPI pseudo-continuous ASL (PCASL) sequence implemented on 3T scanners from three vendors (General Electric Healthcare, Philips Healthcare and Siemens Healthcare) within the same center and with the same subjects.Material and methodsFourteen healthy volunteers (50% male, age 26.4 ± 4.7 years) were scanned twice on each scanner in an interleaved manner within 3 h. Because of differences in gradient and coil specifications, two separate studies were performed with slightly different sequence parameters, with one scanner used across both studies for comparison. Reproducibility was evaluated by means of quantitative cerebral blood flow (CBF) agreement and inter-session variation, both on a region-of-interest (ROI) and voxel level. In addition, a qualitative similarity comparison of the CBF maps was performed by three experienced neuro-radiologists.ResultsThere were no CBF differences between vendors in study 1 (p > 0.1), but there were CBF differences of 2–19% between vendors in study 2 (p < 0.001 in most gray matter ROIs) and 10–22% difference in CBF values obtained with the same vendor between studies (p < 0.001 in most gray matter ROIs). The inter-vendor inter-session variation was not significantly larger than the intra-vendor variation in all (p > 0.1) but one of the ROIs (p < 0.001).ConclusionThis study demonstrates the possibility to acquire comparable cerebral CBF maps on scanners of different vendors. Small differences in sequence parameters can have a larger effect on the reproducibility of ASL than hardware or software differences between vendors. These results suggest that researchers should strive to employ identical labeling and readout strategies in multi-center ASL studies.
Original languageEnglish
Pages (from-to)143-152
Number of pages10
Publication statusPublished - 1 Jun 2015


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