Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying

Laura Modica De Mohac, Bahijja Raimi-Abraham, Roberto Caruana, Giammona Gaetano, Mariano Licciardi*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

17 Citations (Scopus)

Abstract

The term “multicomponent solid dispersion” is widely used in recent literature to describe solid formulations consisting of a special excipient's mixture and active molecules finely dispersed. However, this term has not yet been defined. In this review, we aimed to improve the definition of multicomponent solid dispersions as a new generation of solid dispersions capable to improve both formulation issues and the therapeutic effect of the final dosage form. As it is well-known the use of solid dispersions to improve drug dissolution rate and solubility, this review describes the field of solid dispersions as well as the formulation strategies available for their production. In particular, the review highlights the use of the spray-drying technique and the benefits provided by this method in the manufacturing of multicomponent solid dispersion.

Original languageEnglish
Article number101750
JournalJournal of drug delivery science and technology
Volume57
DOIs
Publication statusPublished - Jun 2020

Keywords

  • Dissolution rates
  • Dosage form
  • Multicomponent solid dispersion
  • Polymers
  • Spray-drying

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