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Multilayer nanoencapsulation: A nanomedicine technology for diabetes research and management

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)162-9
Number of pages8
JournalDiabetes Research and Clinical Practice
Volume100
Issue number2
DOIs
PublishedMay 2013

Bibliographical note

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

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    1_s2.0_S0168822712004925_main.pdf, 0.98 MB, application/pdf

    Uploaded date:11 Nov 2015

    Version:Final published version

    Licence:CC BY-ND

King's Authors

Abstract

Nanothickness encapsulation using a layer-by-layer technique has applications in several areas of diabetes research, including improved glucose sensors, islet cell transplantation and oral insulin delivery. We have fabricated microvesicles containing a fluorescence lifetime-based glucose sensing system, with bacterial glucose-binding protein as the glucose receptor. Such sensors are suitable for impregnation in the dermis as a 'smart tattoo' type of non-invasive glucose monitoring technology. Nanoencapsulation of islet cells is intended to alleviate the immediate blood-mediated inflammatory reaction which is responsible for early islet loss post-transplant. In an allogeneic diabetic mouse model, nanoencapsulated islets with phosporylcholine-modified polysaccharide coating, significantly extended survival of transplanted islets. In early studies aimed at formulating an effective oral insulin preparation, insulin-chitosan colloids coated with nanolayers of chitosan and heparin had enhanced acid stability and effectively lowered blood glucose in an animal model.

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