King's College London

Research portal

Multilayer nanoencapsulation: A nanomedicine technology for diabetes research and management

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)162-9
Number of pages8
JournalDiabetes Research and Clinical Practice
Issue number2
PublishedMay 2013

Bibliographical note

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.


  • 1_s2.0_S0168822712004925_main

    1_s2.0_S0168822712004925_main.pdf, 0.98 MB, application/pdf

    Uploaded date:11 Nov 2015

    Version:Final published version

    Licence:CC BY-ND

King's Authors


Nanothickness encapsulation using a layer-by-layer technique has applications in several areas of diabetes research, including improved glucose sensors, islet cell transplantation and oral insulin delivery. We have fabricated microvesicles containing a fluorescence lifetime-based glucose sensing system, with bacterial glucose-binding protein as the glucose receptor. Such sensors are suitable for impregnation in the dermis as a 'smart tattoo' type of non-invasive glucose monitoring technology. Nanoencapsulation of islet cells is intended to alleviate the immediate blood-mediated inflammatory reaction which is responsible for early islet loss post-transplant. In an allogeneic diabetic mouse model, nanoencapsulated islets with phosporylcholine-modified polysaccharide coating, significantly extended survival of transplanted islets. In early studies aimed at formulating an effective oral insulin preparation, insulin-chitosan colloids coated with nanolayers of chitosan and heparin had enhanced acid stability and effectively lowered blood glucose in an animal model.

Download statistics

No data available

View graph of relations

© 2020 King's College London | Strand | London WC2R 2LS | England | United Kingdom | Tel +44 (0)20 7836 5454